Literature summary extracted from

Brodbeck, M.; Rohling, A.; Wohlleben, W.; Thompson, C.J.; Susstrunk, U.
Nucleoside-diphosphate kinase from Streptomyces coelicolor (1996), Eur. J. Biochem., 239, 208-213.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.7.4.6	-	Streptomyces coelicolor

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.4.6	cAMP	IC50 6 mM, weak, competitive	Streptomyces coelicolor

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.7.4.6	0.085	-	ATP	27°C	Streptomyces coelicolor

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
2.7.4.6	15000	-	4 * 15000, SDS-PAGE	Streptomyces coelicolor
2.7.4.6	66000	-	gel filtration	Streptomyces coelicolor

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.4.6	Streptomyces coelicolor	-	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
2.7.4.6	phosphoprotein	-	Streptomyces coelicolor

Purification (Commentary)

EC Number	Purification (Comment)	Organism
2.7.4.6	-	Streptomyces coelicolor

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
2.7.4.6	400	-	27°C	Streptomyces coelicolor

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.4.6	ATP + dTDP	-	Streptomyces coelicolor	ADP + dTTP	-	?
2.7.4.6	NTP + nucleoside diphosphate	-	Streptomyces coelicolor	NDP + NTP	-	r

Subunits

EC Number	Subunits	Comment	Organism
2.7.4.6	tetramer	4 * 15000, SDS-PAGE	Streptomyces coelicolor

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
2.7.4.6	6	-	IC50 6 mM, weak, competitive	Streptomyces coelicolor	cAMP

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Release 2023.1 (January 2023)