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Literature summary extracted from

  • Agarwal, R.P.; Robison, B.; Parks, R.E.
    Nucleoside diphosphokinase from human erythrocytes (1978), Methods Enzymol., 51, 376-386.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.6 p-chloromercuribenzoate pI 7.3-isoform, DTT restores, but not in the presence of urea, ATP or dTDP protects Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.4.6 additional information
-
additional information Km-values of different pI-enzyme variants of ATP or GTP and TDP or CDP as substrates Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.6 Ca2+ requirement, about half as effective as Mg2+, Mn2+ or Co2+, pI 7.3-enzyme variant Homo sapiens
2.7.4.6 Co2+ requirement Homo sapiens
2.7.4.6 Co2+ equally effective as Mg2+ or Mn2+, pI 7.3-enzyme variant Homo sapiens
2.7.4.6 Mg2+ equally effective as Mn2+ or Co2+, pI 7.3-enzyme variant Homo sapiens
2.7.4.6 Mn2+ requirement Homo sapiens
2.7.4.6 Mn2+ equally effective as Co2+, pI 7.3-enzyme variant Homo sapiens
2.7.4.6 Mn2+ equally effective as Mg2+ Homo sapiens
2.7.4.6 additional information no activation by Cu2+ or monovalent cations Homo sapiens
2.7.4.6 Zn2+ not Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.4.6 80000 100000 erythrocytic enzyme variants Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.6 NDP + NTP Homo sapiens
-
NTP + NDP
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.6 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.4.6 marked isoelectric variability with pIs from 5.4 to 8.3 Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.4.6 ATP + nucleoside diphosphate = ADP + nucleoside triphosphate the catalytic mechanism involves a phosphoenzyme intermediate Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.6 ATP + CDP
-
Homo sapiens ADP + CTP
-
?
2.7.4.6 ATP + dTDP
-
Homo sapiens ADP + dTTP
-
?
2.7.4.6 GTP + CDP
-
Homo sapiens GDP + CTP
-
?
2.7.4.6 GTP + dTDP
-
Homo sapiens GDP + dTTP
-
?
2.7.4.6 NDP + NTP
-
Homo sapiens NTP + NDP
-
r
2.7.4.6 NTP + nucleoside diphosphate substrate: 5-fluoro-UTP Homo sapiens NDP + NTP
-
r
2.7.4.6 NTP + nucleoside diphosphate substrate 8-aza-UDP, human erythrocytic pI-variant 5.8 Homo sapiens NDP + NTP
-
r