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Literature summary extracted from

  • Munier-Lehmann, H.; Burlacu-Miron, S.; Craescu, C.T.; Mantsch, H.H.; Schultz, C.P.
    A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: a predictive and experimental study (1999), Proteins Struct. Funct. Genet., 36, 238-248.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.3 7-deazaadenosine 5'-monophosphate i.e. tubercidine 5'-monophosphate Mycobacterium tuberculosis
2.7.4.3 8-bromo-AMP
-
 Mycobacterium tuberculosis
2.7.4.3 P1,P5-diadenosine 5'-pentaphosphate
-
 Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.4.3 21000
-
 electrospray ionization mass spectroscopy Mycobacterium tuberculosis
2.7.4.3 25000
-
 1 * 25000, SDS-PAGE and deduced from gene sequence Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.3 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.3 ATP + AMP
-
 Mycobacterium tuberculosis ADP + ADP
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.4.3 monomer 1 * 25000, SDS-PAGE and deduced from gene sequence Mycobacterium tuberculosis
2.7.4.3 More structural model of enzyme Mycobacterium tuberculosis

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.4.3 additional information
-
 high thermal stability, Tm 64.8°C Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.4.3 0.25
-
 7-deazaadenosine 5'-monophosphate
-
 Mycobacterium tuberculosis
2.7.4.3 0.55
-
 8-bromo-AMP
-
 Mycobacterium tuberculosis