BRENDA - Enzyme Database

P1,P5-Di(adenosine-5)pentaphosphate, a potent multisubstrate inhibitor of adenylate kinase

Lienhard, G.E.; Secemski, I.I.; J. Biol. Chem. 248, 1121-1123 (1973)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.4.3
adenosine 5'-tetraphosphate
weak
Oryctolagus cuniculus
2.7.4.3
adenosine-5'-pentaphosphate
weak
Oryctolagus cuniculus
2.7.4.3
additional information
not inhibitory: P1,P2-di(adenosine-5')diphosphate, P1,P3-di(adenosine-5') triphosphate, triphosphate, tetrahexaphosphate, tetrametaphosphate, hexametaphosphate
Oryctolagus cuniculus
2.7.4.3
P1,P4-diadenosine tetraphosphate
weak
Oryctolagus cuniculus
2.7.4.3
P1,P5-diadenosine 5'-pentaphosphate
above 100 nM; strong
Oryctolagus cuniculus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.4.3
Mg2+
-
Oryctolagus cuniculus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.4.3
Oryctolagus cuniculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.4.3
muscle
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.4.3
ADP + ADP
-
642599
Oryctolagus cuniculus
ATP + AMP
-
-
-
r
2.7.4.3
ATP + AMP
-
642599
Oryctolagus cuniculus
ADP + ADP
-
642599
Oryctolagus cuniculus
r
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.4.3
adenosine 5'-tetraphosphate
weak
Oryctolagus cuniculus
2.7.4.3
adenosine-5'-pentaphosphate
weak
Oryctolagus cuniculus
2.7.4.3
additional information
not inhibitory: P1,P2-di(adenosine-5')diphosphate, P1,P3-di(adenosine-5') triphosphate, triphosphate, tetrahexaphosphate, tetrametaphosphate, hexametaphosphate
Oryctolagus cuniculus
2.7.4.3
P1,P4-diadenosine tetraphosphate
weak
Oryctolagus cuniculus
2.7.4.3
P1,P5-diadenosine 5'-pentaphosphate
above 100 nM; strong
Oryctolagus cuniculus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.4.3
Mg2+
-
Oryctolagus cuniculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.4.3
muscle
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.4.3
ADP + ADP
-
642599
Oryctolagus cuniculus
ATP + AMP
-
-
-
r
2.7.4.3
ATP + AMP
-
642599
Oryctolagus cuniculus
ADP + ADP
-
642599
Oryctolagus cuniculus
r