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Literature summary extracted from

  • Noda, L.
    Nucleoside triphosphate-nucleoside monophosphokinases (1962), The Enzymes,2nd. Ed. (Boyer,P. D. ,ed. ), 6, 139-149.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.4.3 L-cysteine activation Oryctolagus cuniculus
2.7.4.3 sulfhydryl compounds requirement Oryctolagus cuniculus

General Stability

EC Number General Stability Organism
2.7.4.3 dilution inactivates, inert proteins stabilize Oryctolagus cuniculus
2.7.4.3 high stability towards heat and treatment with acids Oryctolagus cuniculus
2.7.4.3 inactivation by contact with glass or cellophane Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.3 EDTA and other complexing agents Oryctolagus cuniculus
2.7.4.3 F-
-
 Oryctolagus cuniculus
2.7.4.3 KCl 1-2 mM Oryctolagus cuniculus
2.7.4.3 sulfhydryl reagents
-
 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.4.3 additional information
-
 additional information kinetic properties Oryctolagus cuniculus
2.7.4.3 0.03
-
 ADP3- pH 8, 25°C Oryctolagus cuniculus
2.7.4.3 0.09 0.092 ADP3- pH 7.5, 30°C Oryctolagus cuniculus
2.7.4.3 0.27 0.3 ATP
-
 Oryctolagus cuniculus
2.7.4.3 0.5 0.6 AMP
-
 Oryctolagus cuniculus
2.7.4.3 1.58
-
 ADP
-
 Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.3 Mg2+ requirement Oryctolagus cuniculus
2.7.4.3 Mg2+ maximal activity when MgCl2/ADP-ratio: about 0.5 and MgCl2/ATP-ratio: 1 Oryctolagus cuniculus
2.7.4.3 Mn2+ requirement, about 50% as effective as Mg2+ Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.4.3 21000
-
 muscle, sedimentation and diffusion Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.3 Oryctolagus cuniculus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.4.3 ATP + AMP = 2 ADP mechanism Oryctolagus cuniculus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.3 erythrocyte
-
 Oryctolagus cuniculus
-
2.7.4.3 liver
-
 Oryctolagus cuniculus
-
2.7.4.3 muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.3 ADP + ADP no substrates: IDP, GDP Oryctolagus cuniculus ATP + AMP
-
 r
2.7.4.3 ADP + ADP no substrate: UDP Oryctolagus cuniculus ATP + AMP
-
 r
2.7.4.3 ADP + ADP no substrates: adenosine tetraphosphate Oryctolagus cuniculus ATP + AMP
-
 r
2.7.4.3 ADP + diphosphate at 0.1% the rate of the natural substrates Oryctolagus cuniculus ATP + phosphate
-
 ?
2.7.4.3 ATP + AMP no substrate of the reverse reaction: UDP Oryctolagus cuniculus ADP + ADP
-
 r
2.7.4.3 ATP + AMP no substrates of the reverse reaction: adenosine tetraphosphate Oryctolagus cuniculus ADP + ADP
-
 r
2.7.4.3 ATP + AMP no substrates of the reverse reaction: IDP, GDP Oryctolagus cuniculus ADP + ADP
-
 r
2.7.4.3 ATP + AMP no substrates are ATP/UMP Oryctolagus cuniculus ADP + ADP
-
 r
2.7.4.3 ATP + AMP no substrates are ITP/ADP, ATP/UDP Oryctolagus cuniculus ADP + ADP
-
 r
2.7.4.3 CDP + CDP
-
 Oryctolagus cuniculus CTP + CMP
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.4.3 additional information
-
 additional information 26300 for formation of ATP at 30°C, 28000 for formation of ATP at 25°C Oryctolagus cuniculus
2.7.4.3 417
-
 ATP 25°C Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.4.3 8
-
 broad Oryctolagus cuniculus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.4.3 Oryctolagus cuniculus muscle enzyme
-
 6.1