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Literature summary extracted from

  • Blattner, J.; Helfert, S.; Michels, P.; Clayton, C.
    Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism (1998), Proc. Natl. Acad. Sci. USA, 95, 11596-11600.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.2.3 inducible expression of cytosolic isozyme in bloodstream parasites, toxicity depends on the expression level of active enzyme Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.2.3 cytosol in parasites grown in the gut of tsetse fly Trypanosoma brucei 5829
-
2.7.2.3 glycosome in parasites grown in mammalian bloodstream Trypanosoma brucei 20015
-
2.7.2.3 additional information the catalytically active cytosolic isozyme is toxic and lethal for bloodstream parasites Trypanosoma brucei
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.2.3 ADP + 3-phospho-D-glyceroyl phosphate Trypanosoma brucei
-
 ATP + 3-phospho-D-glycerate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.2.3 Trypanosoma brucei
-
 glycosomal PGKA and cytosolic PGKB isozymes
-
2.7.2.3 Trypanosoma brucei
-
 from mammalian blood stream and the gut of tsetse fly
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.3 ADP + 3-phospho-D-glyceroyl phosphate
-
 Trypanosoma brucei ATP + 3-phospho-D-glycerate
-
 r
2.7.2.3 ATP + 3-phospho-D-glycerate
-
 Trypanosoma brucei ADP + 1,3-diphosphoglycerate
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.2.3 ADP
-
 Trypanosoma brucei
2.7.2.3 ATP required as phosphate donor Trypanosoma brucei