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Literature summary extracted from

  • McHarg, J.; Littlechild, J.A.
    Studies with inhibitors of the glycolytic enzyme phosphoglycerate kinase for potential treatment of cardiovascular and respiratory disorders (1996), J. Pharm. Pharmacol., 48, 201-205.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.2.3 medicine inhibition of the enzyme can provide a method of treatment for cardiovascular and respiratory disorders, construction of possible specific fluoro-phosphonate inhibitors Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.2.3 overexpression in Saccharomyces cerevisiae Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.2.3 1,3-bis(difluoro)-1,3-diphospho-2-dihydroxypropane phosphonate analogues of 1,3-diphosphoglycerate Saccharomyces cerevisiae
2.7.2.3 1,4-bis(difluoro)-1,4-diphospho-diethylether phosphonate analogues of 1,3-diphosphoglycerate Saccharomyces cerevisiae
2.7.2.3 additional information
-
 Homo sapiens
2.7.2.3 additional information inhibitory effect of phosphonate analogues of 1,3-diphosphoglycerate, overview Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.2.3 Mg2+
-
 Homo sapiens
2.7.2.3 Mg2+
-
 Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.7.2.3 Homo sapiens
-
-
-
2.7.2.3 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.3 ATP + 3-phospho-D-glycerate
-
 Homo sapiens ADP + 1,3-diphosphoglycerate
-
 r
2.7.2.3 ATP + 3-phospho-D-glycerate
-
 Saccharomyces cerevisiae ADP + 1,3-diphosphoglycerate
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.2.3 7.5
-
 assay at Homo sapiens
2.7.2.3 7.5
-
 assay at Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.2.3 ADP
-
 Homo sapiens
2.7.2.3 ADP
-
 Saccharomyces cerevisiae
2.7.2.3 ATP true substrate is the magnesium complexes of ATP Homo sapiens
2.7.2.3 ATP true substrate is the magnesium complexes of ATP Saccharomyces cerevisiae
2.7.2.3 ATP required as phosphate donor Homo sapiens
2.7.2.3 ATP required as phosphate donor Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.2.3 additional information
-
 additional information Ki-values for phosphonate analogues of 1,3-diphosphoglycerate Saccharomyces cerevisiae
2.7.2.3 1.44 1.5 1,3-bis(difluoro)-1,3-diphospho-2-dihydroxypropane pH 7.5, 25°C Saccharomyces cerevisiae
2.7.2.3 3.25 3.3 1,4-bis(difluoro)-1,4-diphospho-diethylether pH 7.5, 25°C Saccharomyces cerevisiae