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Literature summary extracted from

  • Holness, M.J.; Bulmer, K.; Smith, N.D.; Sugden, M.C.
    Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone (2003), Biochem. J., 369, 687-695.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.2 Lipid enhance expression of hepatic isozyme PDK2 during high-fat feeding Rattus norvegicus
2.7.11.2 additional information during hyperthyroidism, the expression of hepatic isozymes PDK2 and PDK4 is increased Rattus norvegicus
2.7.11.2 additional information starvation increases expression of isozyme PDK4 Rattus norvegicus
2.7.11.2 peroxisome proliferator-activated receptor-alpha involved in mechanism to enhance expression of isozyme PDK4, but not isozyme PDK2, during starvation Rattus norvegicus
2.7.11.2 WY-14,643 activator of peroxisome proliferator-activated receptor-alpha Rattus norvegicus
2.7.11.2 WY-14,643 in liver, specifically increases PDK4 expression Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus tissue-specific regulation of the pyruvate dehydrogenase complex in order to adjust glucose consumption ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus high-fat feeding increases the expression of isozyme PDK2, but not of PDK4, hyperthyroidism increases the expression of both isozymes, physiological implications ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.2 Rattus norvegicus
-
 female Wistar rats
-
2.7.11.2 Rattus norvegicus
-
 isozymes PDK2 and PDK4
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.2 liver a complex signalling mechanism mediates the regulation of the isozymes PDK2 and PDK4 in response to the feeding status of the organism, overview Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)]
-
 Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] tissue-specific regulation of the pyruvate dehydrogenase complex in order to adjust glucose consumption Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] high-fat feeding increases the expression of isozyme PDK2, but not of PDK4, hyperthyroidism increases the expression of both isozymes, physiological implications Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir

Synonyms

EC Number Synonyms Comment Organism
2.7.11.2 PDK
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.2 ATP dependent on Rattus norvegicus