EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.2 | dihydrolipoyl transacetylase | requirement | Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.11.2 | expression of His-tagged isozymes PDK1 and PDK2 in Escherichia coli BL21(DE3) | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.2 | (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropioamide | strong inhibition, isozymes PDK1 and PDK2, inhibition mechanism | Rattus norvegicus | |
2.7.11.2 | adenosine 5'-[beta,gamma,imido]triphosphate | isozymes PDK1 and PDK2, inhibition mechanism | Rattus norvegicus | |
2.7.11.2 | Dichloroacetate | - |
Rattus norvegicus | |
2.7.11.2 | dichloroacetophenone | isozymes PDK1 and PDK2, inhibition mechanism | Rattus norvegicus | |
2.7.11.2 | lactone derivative of dichloroacetophenone | isozymes PDK1 and PDK2, inhibition mechanism | Rattus norvegicus | |
2.7.11.2 | triterpenes | isozymes PDK1 and PDK2, inhibition mechanism | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | Rattus norvegicus | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.2 | Rattus norvegicus | - |
isozymes PDK1 and PDK2 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.11.2 | recombinant His-tagged isozymes PDK1 and PDK2 expressed in Escherichia coli BL21(DE3) | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.2 | ATP + Ac-YHGHSMSDPGVSYR | recombinant enzyme | Rattus norvegicus | ADP + [Ac-YHGHSMSDPGVSYR]phosphate | - |
? | |
2.7.11.2 | ATP + Ac-YHGHSMSDPGVSYR | synthetic peptide substrate | Rattus norvegicus | ADP + [Ac-YHGHSMSDPGVSYR]phosphate | - |
? | |
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | pyruvate dehydrogenase complex substrate is inactivated by ATP-dependent phosphorylation of 3 serine residues on the E1 subunit | Rattus norvegicus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | Rattus norvegicus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
2.7.11.2 | additional information | performs autophosphorylation | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.2 | PDK | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.2 | ATP | dependent on | Rattus norvegicus |