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Literature summary extracted from

  • Sugden, M.C.; Langdown, M.L.; Harris, R.A.; Holness, M.J.
    Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply (2000), Biochem. J., 352, 731-738.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.2 Lipid selective increase in amount of isozyme PDHK4 protein in both hyperthyroidism and high-fat feeding Rattus norvegicus
2.7.11.2 Thyroid hormones selective increase in amount of isozyme PDHK4 protein in both hyperthyroidism and high-fat feeding Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.2 pyruvate isozyme PDHK4 is less sensitive than PDHK1 and PDHK2 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.2 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus enzyme regulation in the heart depends on thyroid hormone and lipid status ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus enzyme regulates glucose oxidation by pyruvate dehydrogenase complex, isozyme PDHK1 is of more potential importance in adult heart than the other isozymes ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.2 Rattus norvegicus
-
 female Wistar rats
-
2.7.11.2 Rattus norvegicus
-
 selective increase in amount of PDHK4 protein in both hyperthyroidism and high-fat feeding
-
2.7.11.2 Rattus norvegicus
-
 3 isozymes PDHK1, PDHK2, PDHK4
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.2 heart developing and adult heart, the latter contains 3 isozymes: PDHK1, PDHK2 and PDHK4, clear differences in protein expression patterns of the isoforms dependent on developmental stage, overview Rattus norvegicus
-
2.7.11.2 additional information selective increase in amount of isozyme PDHK4 protein in both hyperthyroidism and high-fat feeding Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.2 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)]
-
 Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] enzyme regulation in the heart depends on thyroid hormone and lipid status Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] enzyme regulates glucose oxidation by pyruvate dehydrogenase complex, isozyme PDHK1 is of more potential importance in adult heart than the other isozymes Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir

Synonyms

EC Number Synonyms Comment Organism
2.7.11.2 PDH kinase
-
 Rattus norvegicus
2.7.11.2 PDHK
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.2 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.2 7 7.4 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.2 ATP dependent on Rattus norvegicus