Literature summary extracted from
Robertson, J.G.; Barron, L.L.; Olson, M.S.
Bovine heart pyruvate dehydrogenase kinase stimulation by alpha-ketoisovalerate (1990), J. Biol. Chem., 265, 16814-16820.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
2.7.11.2 |
2-oxoisopentanoate |
only in the presence of K+ and thiamine diphosphate, kinetics |
Bos taurus |
|
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
2.7.11.2 |
thiamine diphosphate |
kinetics; non- or uncompetitively inhibition of K+-stimulated activity |
Bos taurus |
|
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
Metals/Ions
EC Number |
Metals/Ions |
Comment |
Organism |
Structure |
---|
2.7.11.2 |
Mg2+ |
requirement |
Bos taurus |
|
Natural Substrates/ Products (Substrates)
EC Number |
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
---|
2.7.11.2 |
ATP + [pyruvate dehydrogenase (lipoamide)] |
Bos taurus |
catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 |
ADP + [pyruvate dehydrogenase (lipoamide)] phosphate |
- |
ir |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.7.11.2 |
Bos taurus |
- |
- |
- |
Reaction
EC Number |
Reaction |
Comment |
Organism |
Reaction ID |
---|
2.7.11.2 |
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate |
mechanism |
Bos taurus |
|
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
2.7.11.2 |
heart |
- |
Bos taurus |
- |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
2.7.11.2 |
ATP + [pyruvate dehydrogenase (lipoamide)] |
- |
Bos taurus |
ADP + [pyruvate dehydrogenase (lipoamide)] phosphate |
- |
ir |
|
2.7.11.2 |
ATP + [pyruvate dehydrogenase (lipoamide)] |
catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 |
Bos taurus |
ADP + [pyruvate dehydrogenase (lipoamide)] phosphate |
- |
ir |
|
Temperature Optimum [°C]
EC Number |
Temperature Optimum [°C] |
Temperature Optimum Maximum [°C] |
Comment |
Organism |
---|
2.7.11.2 |
30 |
- |
assay at |
Bos taurus |
Cofactor
EC Number |
Cofactor |
Comment |
Organism |
Structure |
---|
2.7.11.2 |
ATP |
dependent on |
Bos taurus |
|
Ki Value [mM]
EC Number |
Ki Value [mM] |
Ki Value maximum [mM] |
Inhibitor |
Comment |
Organism |
Structure |
---|
2.7.11.2 |
additional information |
- |
additional information |
inhibition kinetics for thiamine diphosphate |
Bos taurus |
|