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Literature summary extracted from

  • Rahmatullah, M.; Roche, T.E.
    Modification of bovine kidney pyruvate dehydrogenase kinase activity by CoA esters and their mechanism of action (1985), J. Biol. Chem., 260, 10146-10152.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.2 2-oxoisopentanoate
-
 Bos taurus
2.7.11.2 acetoacetyl-CoA slight activation Bos taurus
2.7.11.2 acetyl-CoA synergism with NADH Bos taurus
2.7.11.2 benzoyl-CoA slight activation Bos taurus
2.7.11.2 L-methylmalonyl-CoA slight activation Bos taurus
2.7.11.2 malonyl-CoA
-
 Bos taurus
2.7.11.2 NADH activation, in the presence of K+ Bos taurus
2.7.11.2 propionyl-CoA slight activation at low concentrations, synergism with NADH plus NAD+ Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.2 butyryl-CoA at high concentrations Bos taurus
2.7.11.2 decanoyl-CoA
-
 Bos taurus
2.7.11.2 hexanoyl-CoA
-
 Bos taurus
2.7.11.2 linolenoyl-CoA
-
 Bos taurus
2.7.11.2 linoleoyl-CoA
-
 Bos taurus
2.7.11.2 additional information no inhibition by succinyl-CoA, tiglyl-CoA, crotonyl-CoA, glutaryl-CoA, DL-3-hydroxy-3-methylglutaryl-CoA, acetylcarnitine or 3-hydroxybutyryl-CoA Bos taurus
2.7.11.2 myristoyl-CoA
-
 Bos taurus
2.7.11.2 oleoyl-CoA
-
 Bos taurus
2.7.11.2 stearoyl-CoA
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.2 Mg2+ requirement Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] Bos taurus catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.2 kidney
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)]
-
 Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.2 30
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.2 7.3
-
 assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.2 ATP dependent on Bos taurus
2.7.11.2 additional information no activation by succinyl-CoA, tiglyl-CoA, crotonyl-CoA, glutaryl-CoA, DL-3-hydroxy-3-methylglutaryl-CoA, acetylcarnitine or 3-hydroxybutyryl-CoA Bos taurus