EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.81 | 2-Amino-5-hydroxyadipate | 4 isomers, 40 mM, strong inhibition | Rattus norvegicus | |
2.7.1.81 | 4,5-Dehydro-(trans)-L-lysine | - |
Rattus norvegicus | |
2.7.1.81 | carnitine | 2 isomers | Rattus norvegicus | |
2.7.1.81 | choline | 40 mM, weak inhibition | Rattus norvegicus | |
2.7.1.81 | D-Lysine | - |
Rattus norvegicus | |
2.7.1.81 | D-ornithine | - |
Rattus norvegicus | |
2.7.1.81 | ethanolamine | 40 mM, weak inhibition | Rattus norvegicus | |
2.7.1.81 | Hydroxy-L-pipecolate | - |
Rattus norvegicus | |
2.7.1.81 | hydroxy-L-proline | 40 mM, strong | Rattus norvegicus | |
2.7.1.81 | L-2,4-diamino-n-butyrate | - |
Rattus norvegicus | |
2.7.1.81 | L-homoserine | 40 mM, weak inhibition | Rattus norvegicus | |
2.7.1.81 | L-lysine | higher inhibitory effect than with D-lysine | Rattus norvegicus | |
2.7.1.81 | L-ornithine | higher inhibitory effect than with D-ornithine | Rattus norvegicus | |
2.7.1.81 | Mn2+ | at 1 mM, in presence of 1 mM Mg2+, strong inhibition, but activation in absence of Mg2+ | Rattus norvegicus | |
2.7.1.81 | S-aminoethyl-L-cysteine | - |
Rattus norvegicus | |
2.7.1.81 | Zn2+ | at 1 mM, in presence of 1 mM Mg2+, strong inhibition | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.81 | 0.0056 | - |
hydroxy-L-lysine | pH 8.0, 37°C | Rattus norvegicus | |
2.7.1.81 | 0.0062 | - |
allohydroxy-L-lysine | pH 8.0, 37°C | Rattus norvegicus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.81 | Ca2+ | requirement of a divalent metal ion, 1 mM, 13% of activity compared to Mg2+ | Rattus norvegicus | |
2.7.1.81 | Co2+ | requirement of a divalent metal ion, 1 mM, 13% of activity compared to Mg2+ | Rattus norvegicus | |
2.7.1.81 | Cu2+ | requirement of a divalent metal ion, 1 mM, 13% of activity compared to Mg2+ | Rattus norvegicus | |
2.7.1.81 | Fe2+ | requirement of a divalent metal ion, 1 mM, 13% of activity compared to Mg2+ | Rattus norvegicus | |
2.7.1.81 | Hg2+ | requirement of a divalent metal ion, 1 mM, 13% of activity compared to Mg2+ | Rattus norvegicus | |
2.7.1.81 | Mg2+ | requirement of a divalent metal ion, Mg2+ yields highest activity | Rattus norvegicus | |
2.7.1.81 | Mn2+ | requirement of a divalent metal ion, 1 mM, 13% of activity compared to Mg2+, strong inhibition in presence of 1 mM Mg2+ | Rattus norvegicus | |
2.7.1.81 | additional information | K+, Li+ have no influence | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.81 | GTP + 5-hydroxy-L-lysine | Rattus norvegicus | erythro-5-hydroxy-L8-lysine | GDP + O-phosphohydroxy-L-lysine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.81 | Bos taurus | - |
- |
- |
2.7.1.81 | Cebus albifrons | - |
- |
- |
2.7.1.81 | Chlorocebus aethiops | - |
- |
- |
2.7.1.81 | Gallus gallus | - |
- |
- |
2.7.1.81 | Mus musculus | - |
- |
- |
2.7.1.81 | no activity in Homo sapiens | - |
no activity in liver and kidney | - |
2.7.1.81 | Oryctolagus cuniculus | - |
- |
- |
2.7.1.81 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.81 | 1200fold | Rattus norvegicus |
2.7.1.81 | partial | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.81 | kidney | - |
Mus musculus | - |
2.7.1.81 | kidney | - |
Rattus norvegicus | - |
2.7.1.81 | kidney | - |
Oryctolagus cuniculus | - |
2.7.1.81 | kidney | - |
Chlorocebus aethiops | - |
2.7.1.81 | kidney | - |
Cebus albifrons | - |
2.7.1.81 | liver | - |
Gallus gallus | - |
2.7.1.81 | liver | - |
Mus musculus | - |
2.7.1.81 | liver | - |
Rattus norvegicus | - |
2.7.1.81 | liver | - |
Bos taurus | - |
2.7.1.81 | liver | - |
Oryctolagus cuniculus | - |
2.7.1.81 | liver | - |
Cebus albifrons | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.1.81 | 0.114 | - |
- |
Rattus norvegicus |
EC Number | Storage Stability | Organism |
---|---|---|
2.7.1.81 | frozen, little loss of activity for weeks | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.81 | GTP + 5-hydroxy-L-lysine | erythro-5-hydroxy-L8-lysine | Rattus norvegicus | GDP + O-phosphohydroxy-L-lysine | - |
? | |
2.7.1.81 | GTP + allohydroxy-L-lysine | - |
Rattus norvegicus | ? | - |
? | |
2.7.1.81 | additional information | no activity with D-isomers, ITP can partially substitute for GTP | Rattus norvegicus | ? | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.81 | 37 | - |
assay at | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.81 | 7.7 | - |
- |
Rattus norvegicus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.81 | 6 | 9 | 25% of maximal activity at pH 6.0, 35% of maximal activity at pH 9.0 | Rattus norvegicus |