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Literature summary extracted from

  • Kierdaszuk, B.; Krawiec, K.; Kazimierczuk, Z.; Jacobsson, U.; Johansson, N.G.; Munch-Petersen, B.; Eriksson, S.; Shugar, D.
    Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O'-alkyl analogues (1999), Nucleosides Nucleotides, 18, 1883-1903.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.74 2'-O-methylcytidine
-
 Homo sapiens
2.7.1.74 3'-O-methyl-2'deoxycytidine
-
 Homo sapiens
2.7.1.74 5'-O-ethyl-2'-deoxycytidine
-
 Homo sapiens
2.7.1.74 5'-O-methyl-2'-deoxycytidine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 leukemia cell from spleen Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 2',2'-difluoro-2'-deoxyguanosine + ATP
-
 Homo sapiens ADP + 2',2'-difluoro-2'-deoxyguanosine 5'-phosphate
-
 ?
2.7.1.74 2'-fluoro-2'-deoxyarabinosylcytidine + ATP
-
 Homo sapiens ADP + 2'-fluoro-2'-deoxyarabinosylcytidine 5'-phosphate
-
 ?
2.7.1.74 2'-fluoro-2'-deoxycytidine + ATP
-
 Homo sapiens ADP + 2'-fluoro-2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 2'-O-methyl-cytidine + ATP
-
 Homo sapiens ADP + 2'-O-methyl-cytidine 5'-phosphate
-
 ?
2.7.1.74 2-chloro-2'-deoxyadenosine + NTP
-
 Homo sapiens NDP + 2-chloro-2'-deoxy-AMP
-
 ?
2.7.1.74 3'-O-methyl-2'-deoxycytidine + ATP
-
 Homo sapiens ADP + 3'-O-methyl-2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 9-(beta-D-arabinofuranosyl)-adenine + ATP
-
 Homo sapiens 9-(beta-D-arabinofuranosyl)-adenine 5'-phosphate + ADP
-
 ?
2.7.1.74 beta-D-3'-hydroxymethyl-2',3'dideoxycytidine + ATP
-
 Homo sapiens ADP + beta-D-3'-hydroxymethyl-2',3'dideoxycytidine 5'-phosphate
-
 ?
2.7.1.74 NTP + cytosine arabinoside
-
 Homo sapiens NDP + cytosine arabinoside 5'-monophosphate
-
 ?
2.7.1.74 NTP + deoxyadenosine
-
 Homo sapiens NDP + dAMP
-
 ?
2.7.1.74 NTP + deoxycytidine
-
 Homo sapiens NDP + dCMP
-
 ?
2.7.1.74 NTP + deoxyguanosine
-
 Homo sapiens NDP + dGMP
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.74 0.02
-
 3'-O-methyl-2'deoxycytidine 37°C, pH 7.6 Homo sapiens
2.7.1.74 0.032
-
 5'-O-ethyl-2'-deoxycytidine 37°C, pH 7.6 Homo sapiens
2.7.1.74 0.23
-
 5'-O-methyl-2'-deoxycytidine 37°C, pH 7.6 Homo sapiens
2.7.1.74 0.3
-
 2'-O-methylcytidine 37°C, pH 7.6 Homo sapiens