BRENDA - Enzyme Database show

Deoxycytidine kinase: properties of the enzyme from human leukemic granulocytes

Coleman, C.N.; Stoller, R.G.; Drake, J.C.; Chabner, B.A.; Blood 46, 791-803 (1975)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.74
Cytosine arabinoside triphosphate
weak
Homo sapiens
2.7.1.74
dCTP
cytosine arabinoside as substrate
Homo sapiens
2.7.1.74
deoxycytidine
cytosine arabinoside as substrate
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.1.74
0.0033
0.0093
deoxycytidine
-
Homo sapiens
2.7.1.74
0.02
0.04
cytosine arabinoside
D-isomer
Homo sapiens
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.7.1.74
68000
-
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Homo sapiens
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
2.7.1.74
partial
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
leukemia cell
from acute myeloid leukemia (AML) patients
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
641948
Homo sapiens
ADP + 5'-dCMP
-
-
-
?
2.7.1.74
GTP + 2'-deoxycytidine
-
641948
Homo sapiens
GDP + 2'-deoxy-CMP
-
-
-
?
2.7.1.74
NTP + cytosine arabinoside
-
641948
Homo sapiens
NDP + cytosine arabinoside 5'-monophosphate
-
-
-
?
2.7.1.74
NTP + deoxycytidine
-
641948
Homo sapiens
NDP + dCMP
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.74
Cytosine arabinoside triphosphate
weak
Homo sapiens
2.7.1.74
dCTP
cytosine arabinoside as substrate
Homo sapiens
2.7.1.74
deoxycytidine
cytosine arabinoside as substrate
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.1.74
0.0033
0.0093
deoxycytidine
-
Homo sapiens
2.7.1.74
0.02
0.04
cytosine arabinoside
D-isomer
Homo sapiens
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.7.1.74
68000
-
-
Homo sapiens
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.7.1.74
partial
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
leukemia cell
from acute myeloid leukemia (AML) patients
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
641948
Homo sapiens
ADP + 5'-dCMP
-
-
-
?
2.7.1.74
GTP + 2'-deoxycytidine
-
641948
Homo sapiens
GDP + 2'-deoxy-CMP
-
-
-
?
2.7.1.74
NTP + cytosine arabinoside
-
641948
Homo sapiens
NDP + cytosine arabinoside 5'-monophosphate
-
-
-
?
2.7.1.74
NTP + deoxycytidine
-
641948
Homo sapiens
NDP + dCMP
-
-
-
?