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Deoxynucleoside phosphorylating enzymes in monkey and human tissues show great similarities, while mouse deoxycytidine kinase has a different substrate specificity

Habteyesus, A.; Nordenskjoeld, A.; Bohman, C.; Eriksson, S.; Biochem. Pharmacol. 42, 1829-1836 (1991)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.74
cytosol
-
Aotus trivirgatus
5829
-
2.7.1.74
cytosol
-
Mus musculus
5829
-
2.7.1.74
cytosol
-
Homo sapiens
5829
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.7.1.74
30000
-
2 * 30000, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
ATP + deoxycytidine
Mus musculus
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
ADP + ?
-
-
?
2.7.1.74
ATP + deoxycytidine
Homo sapiens
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
ADP + ?
-
-
?
2.7.1.74
ATP + deoxycytidine
Aotus trivirgatus
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
ADP + ?
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Aotus trivirgatus
-
-
-
2.7.1.74
Homo sapiens
-
-
-
2.7.1.74
Mus musculus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
2.7.1.74
spleen
Mus musculus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
liver
-
Aotus trivirgatus
-
2.7.1.74
liver
-
Homo sapiens
-
2.7.1.74
liver
-
Mus musculus
-
2.7.1.74
spleen
-
Aotus trivirgatus
-
2.7.1.74
spleen
-
Homo sapiens
-
2.7.1.74
spleen
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + deoxycytidine
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
641947
Mus musculus
ADP + ?
-
-
-
?
2.7.1.74
ATP + deoxycytidine
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
641947
Homo sapiens
ADP + ?
-
-
-
?
2.7.1.74
ATP + deoxycytidine
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
641947
Aotus trivirgatus
ADP + ?
-
-
-
?
2.7.1.74
NTP + 2',3'-dideoxycytidine
poor
641947
Mus musculus
NDP + 2',3'-dideoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
NTP + deoxyadenosine
-
641947
Homo sapiens
NDP + dAMP
-
-
-
?
2.7.1.74
NTP + deoxyadenosine
-
641947
Aotus trivirgatus
NDP + dAMP
-
-
-
?
2.7.1.74
NTP + deoxyadenosine
poor
641947
Mus musculus
NDP + dAMP
-
-
-
?
2.7.1.74
NTP + deoxycytidine
-
641947
Mus musculus
NDP + dCMP
-
-
-
?
2.7.1.74
NTP + deoxycytidine
-
641947
Homo sapiens
NDP + dCMP
-
-
-
?
2.7.1.74
NTP + deoxycytidine
-
641947
Aotus trivirgatus
NDP + dCMP
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
2.7.1.74
dimer
-
Homo sapiens
2.7.1.74
dimer
2 * 30000, SDS-PAGE
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.74
cytosol
-
Aotus trivirgatus
5829
-
2.7.1.74
cytosol
-
Mus musculus
5829
-
2.7.1.74
cytosol
-
Homo sapiens
5829
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.7.1.74
30000
-
2 * 30000, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
ATP + deoxycytidine
Mus musculus
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
ADP + ?
-
-
?
2.7.1.74
ATP + deoxycytidine
Homo sapiens
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
ADP + ?
-
-
?
2.7.1.74
ATP + deoxycytidine
Aotus trivirgatus
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
ADP + ?
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.7.1.74
spleen
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
liver
-
Aotus trivirgatus
-
2.7.1.74
liver
-
Homo sapiens
-
2.7.1.74
liver
-
Mus musculus
-
2.7.1.74
spleen
-
Aotus trivirgatus
-
2.7.1.74
spleen
-
Homo sapiens
-
2.7.1.74
spleen
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + deoxycytidine
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
641947
Mus musculus
ADP + ?
-
-
-
?
2.7.1.74
ATP + deoxycytidine
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
641947
Homo sapiens
ADP + ?
-
-
-
?
2.7.1.74
ATP + deoxycytidine
key enzyme in anabolic phosphorylation of deoxyribonucleosides and their analogues
641947
Aotus trivirgatus
ADP + ?
-
-
-
?
2.7.1.74
NTP + 2',3'-dideoxycytidine
poor
641947
Mus musculus
NDP + 2',3'-dideoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
NTP + deoxyadenosine
-
641947
Homo sapiens
NDP + dAMP
-
-
-
?
2.7.1.74
NTP + deoxyadenosine
-
641947
Aotus trivirgatus
NDP + dAMP
-
-
-
?
2.7.1.74
NTP + deoxyadenosine
poor
641947
Mus musculus
NDP + dAMP
-
-
-
?
2.7.1.74
NTP + deoxycytidine
-
641947
Mus musculus
NDP + dCMP
-
-
-
?
2.7.1.74
NTP + deoxycytidine
-
641947
Homo sapiens
NDP + dCMP
-
-
-
?
2.7.1.74
NTP + deoxycytidine
-
641947
Aotus trivirgatus
NDP + dCMP
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.7.1.74
dimer
-
Homo sapiens
2.7.1.74
dimer
2 * 30000, SDS-PAGE
Mus musculus