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Literature summary extracted from

  • Sabater, B.; Sebastian, J.; Asensio, C.
    Identification and properties of an inducible mannokinase from Streptomyces violaceoruber (1972), Biochim. Biophys. Acta, 284, 406-413.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.7 2-deoxy-D-mannose
-
Streptomyces violaceoruber
2.7.1.7 alpha-Methyl-D-mannosamine
-
Streptomyces violaceoruber
2.7.1.7 D-glucose
-
Streptomyces violaceoruber
2.7.1.7 D-mannoheptulose
-
Streptomyces violaceoruber
2.7.1.7 D-mannosamine
-
Streptomyces violaceoruber
2.7.1.7 D-mannose 6-phosphate up to 20 mM no effect Streptomyces violaceoruber
2.7.1.7 lyxose L-isomer Streptomyces violaceoruber
2.7.1.7 MgADP- competitive Streptomyces violaceoruber
2.7.1.7 N-acetyl-D-mannosamine
-
Streptomyces violaceoruber

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.7 0.05
-
D-mannose
-
Streptomyces violaceoruber
2.7.1.7 0.4
-
mannoheptulose pH 7.5, 25°C Streptomyces violaceoruber
2.7.1.7 15
-
2-deoxy-D-mannose pH 7.5, 25°C Streptomyces violaceoruber
2.7.1.7 20
-
D-mannosamine pH 7.5, 25°C Streptomyces violaceoruber

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.7 Co2+ activates with 40% of the activity with Mg2+ Streptomyces violaceoruber
2.7.1.7 Mg2+ required Streptomyces violaceoruber
2.7.1.7 Mg2+ optimal Mg2+/ATP ratio is 2 Streptomyces violaceoruber
2.7.1.7 Mg2+ Km: 0.4 mM Streptomyces violaceoruber
2.7.1.7 Mn2+ activates with 25% of the activity with Mg2+ Streptomyces violaceoruber

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.7 Streptomyces violaceoruber
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.7
-
Streptomyces violaceoruber

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.7 mycelium
-
Streptomyces violaceoruber
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.7 7.5
-
-
Streptomyces violaceoruber

Storage Stability

EC Number Storage Stability Organism
2.7.1.7 0-2°C, 1 month, 25% loss of activity Streptomyces violaceoruber
2.7.1.7 15°C, 8 months, 25% loss of activity Streptomyces violaceoruber

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.7 ATP + 2-deoxy-D-mannose 25% of the activity with D-mannose Streptomyces violaceoruber ADP + 2-deoxy-D-mannose 6-phosphate
-
?
2.7.1.7 ATP + D-fructose no activity Streptomyces violaceoruber ADP + D-fructose 6-phosphate
-
?
2.7.1.7 ATP + D-fructose reaction is catalyzed by a separate enzyme, EC 2.7.1.4 Streptomyces violaceoruber ADP + D-fructose 6-phosphate
-
?
2.7.1.7 ATP + D-glucose 80% of the activity with D-mannose Streptomyces violaceoruber ADP + D-glucose 6-phosphate
-
?
2.7.1.7 ATP + D-mannosamine 15% of the activity with D-mannose Streptomyces violaceoruber ADP + D-mannosamine 6-phosphate
-
?
2.7.1.7 ATP + D-mannose
-
Streptomyces violaceoruber ADP + mannose 6-phosphate
-
?
2.7.1.7 ATP + mannoheptulose 10% of the activity with D-mannose Streptomyces violaceoruber ADP + mannoheptulose 6-phosphate
-
?
2.7.1.7 CTP + 2-deoxy-D-mannose
-
Streptomyces violaceoruber CDP + 2-deoxy-D-mannose 6-phosphate
-
?
2.7.1.7 CTP + D-glucose
-
Streptomyces violaceoruber CDP + D-glucose 6-phosphate
-
?
2.7.1.7 CTP + D-mannosamine
-
Streptomyces violaceoruber CDP + D-mannosamine 6-phosphate
-
?
2.7.1.7 CTP + D-mannose 10% of the activity with ATP Streptomyces violaceoruber CDP + D-mannose 6-phosphate
-
?
2.7.1.7 CTP + mannoheptulose
-
Streptomyces violaceoruber CDP + mannoheptulose 6-phosphate
-
?
2.7.1.7 GTP + 2-deoxy-D-mannose
-
Streptomyces violaceoruber GDP + 2-deoxy-D-mannose 6-phosphate
-
?
2.7.1.7 GTP + D-glucose
-
Streptomyces violaceoruber GDP + D-glucose 6-phosphate
-
?
2.7.1.7 GTP + D-mannosamine
-
Streptomyces violaceoruber GDP + D-mannosamine 6-phosphate
-
?
2.7.1.7 GTP + D-mannose 40% of the activity with ATP Streptomyces violaceoruber GDP + D-mannose 6-phosphate
-
?
2.7.1.7 GTP + mannoheptulose
-
Streptomyces violaceoruber GDP + mannoheptulose 6-phosphate
-
?
2.7.1.7 ITP + 2-deoxy-D-mannose
-
Streptomyces violaceoruber IDP + 2-deoxy-D-mannose 6-phosphate
-
?
2.7.1.7 ITP + D-glucose
-
Streptomyces violaceoruber IDP + D-glucose 6-phosphate
-
?
2.7.1.7 ITP + D-mannosamine
-
Streptomyces violaceoruber IDP + D-mannosamine 6-phosphate
-
?
2.7.1.7 ITP + D-mannose 90% of the activity with ATP Streptomyces violaceoruber IDP + D-mannose 6-phosphate
-
?
2.7.1.7 ITP + mannoheptulose
-
Streptomyces violaceoruber IDP + mannoheptulose 6-phosphate
-
?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.1.7 65
-
5 min, crude extract, complete loss of activity Streptomyces violaceoruber

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.7 7.5
-
-
Streptomyces violaceoruber

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.7 7 9 activity falls rapidly outside the range 7-9 Streptomyces violaceoruber

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.7 0.1
-
MgADP- pH 7.5, 25°C Streptomyces violaceoruber
2.7.1.7 0.4
-
D-mannoheptulose pH 7.5, 25°C Streptomyces violaceoruber
2.7.1.7 4
-
D-glucose pH 7.5, 25°C Streptomyces violaceoruber
2.7.1.7 15
-
D-Lyxose pH 7.5, 25°C Streptomyces violaceoruber
2.7.1.7 15
-
2-deoxy-D-mannose pH 7.5, 25°C Streptomyces violaceoruber
2.7.1.7 20
-
D-mannosamine pH 7.5, 25°C Streptomyces violaceoruber
2.7.1.7 30
-
alpha-Methyl-D-mannosamine pH 7.5, 25°C Streptomyces violaceoruber
2.7.1.7 75
-
N-acetyl-D-mannosamine pH 7.5, 25°C Streptomyces violaceoruber