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Literature summary extracted from

  • Loijens, J.C.; Anderson, R.A.
    Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family (1996), J. Biol. Chem., 271, 32937-32943.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.68 enzyme form PIP5KIalpha Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.68 membrane
-
 Bos taurus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Bos taurus the product 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is a key precursor in phosphoinositide signaling that also regulates some proteins and cellular processes directly ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.68 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.68
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.68 brain moderate expression of PIP5KIbeta, low expression of PIP5KIalpha Bos taurus
-
2.7.1.68 erythrocyte
-
 Bos taurus
-
2.7.1.68 heart high expression of PIP5KIbeta and PIP5KIalpha Bos taurus
-
2.7.1.68 kidney high expression of PIP5KIbeta Bos taurus
-
2.7.1.68 liver low expression of PIP5KIalpha Bos taurus
-
2.7.1.68 lung low expression of PIP5KIalpha Bos taurus
-
2.7.1.68 pancreas moderate expression of PIP5KIbeta, high expression of PIP5KIalpha Bos taurus
-
2.7.1.68 placenta high expression of PIP5KIbeta Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Bos taurus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate the product 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is a key precursor in phosphoinositide signaling that also regulates some proteins and cellular processes directly Bos taurus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?