Literature summary extracted from

Balla, A.; Tuymetova, G.; Barshishat, M.; Geiszt, M.; Balla, T.
Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments (2002), J. Biol. Chem., 277, 20041-20050.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.7.1.67	endosome	endosome	Homo sapiens	5768	-
2.7.1.67	microsome	-	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.7.1.67	ATP + 1-phosphatidyl-1D-myo-inositol	Homo sapiens	enzyme is involved in the regulation of endosomal membrane traffic in mammalian cells	ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.67	Homo sapiens	Q8TCG2	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
2.7.1.67	COS-7 cells transfected with the HA-tagged PI 4-kinase construct	Homo sapiens

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.67	ATP + 1-phosphatidyl-1D-myo-inositol	-	Homo sapiens	ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	-	?
2.7.1.67	ATP + 1-phosphatidyl-1D-myo-inositol	enzyme is involved in the regulation of endosomal membrane traffic in mammalian cells	Homo sapiens	ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	-	?

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Release 2023.1 (January 2023)