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Literature summary extracted from

  • Yamakawa, A.; Takenawa, T.
    Purification and characterization of membrane-bound phosphatidylinositol kinase from rat brain (1988), J. Biol. Chem., 263, 17555-17560.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.67 Triton X-100 0.1-1.0% w/v, stimulates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 ADP 0.5 mM, 77.4% inhibition Rattus norvegicus
2.7.1.67 AMP 0.5 mM, 70.8% inhibition Rattus norvegicus
2.7.1.67 cAMP 0.5 mM, 10.8% inhibition Rattus norvegicus
2.7.1.67 CDP 0.5 mM, 72.8% inhibition Rattus norvegicus
2.7.1.67 CTP 0.5 mM, 38% inhibition Rattus norvegicus
2.7.1.67 GTP
-
Rattus norvegicus
2.7.1.67 quercetin 1 mM, 36% inhibition Rattus norvegicus
2.7.1.67 SDS 0.05%, complete Rattus norvegicus
2.7.1.67 UTP 0.5 mM, 69% inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.67 0.115
-
phosphatidylinositol pH 7.4, 30°C Rattus norvegicus
2.7.1.67 0.15
-
ATP pH 7.4, 30°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.67 membrane bound to Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.67 Mg2+ the enzyme requires 5-20 mM Mg2+ or 1-2 mM Mn2+ Rattus norvegicus
2.7.1.67 Mn2+ the enzyme requires 5-20 mM Mg2+ or 1-2 mM Mn2+ Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.67 76000
-
1 * 76000, SDS-PAGE Rattus norvegicus
2.7.1.67 80000
-
gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.67
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 brain
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.67 0.143
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
?
2.7.1.67 GTP + 1-phosphatidyl-1D-myo-inositol no activity Rattus norvegicus GDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
?

Subunits

EC Number Subunits Comment Organism
2.7.1.67 monomer 1 * 76000, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.67 7.4
-
broad Rattus norvegicus