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Literature summary extracted from

  • Wetzker, R.; Klinger, R.; Hsuan, J.; Fry, M.J.; Kauffmann-Zeh, A.; Müller, E.; Frunder, H.; Waterfield, M.
    Purification and characterization of phosphatidylinositol 4-kinase from human erythrocyte membranes (1991), Eur. J. Biochem., 200, 179-185.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 adenosine
-
 Homo sapiens
2.7.1.67 Ca2+ inhibition depends in Ca2+ concentration Homo sapiens
2.7.1.67 Co2+
-
 Homo sapiens
2.7.1.67 Fe2+
-
 Homo sapiens
2.7.1.67 Ni2+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.67 0.1
-
 ATP pH 7.2, 37°C Homo sapiens
2.7.1.67 0.2
-
 phosphatidylinositol pH 7.2, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.67 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.67 Mg2+ optimal activation at 10 mM Homo sapiens
2.7.1.67 Mn2+ optimal activation at 0.5 mM Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.67 45000
-
 x * 45000, SDS-PAGE Homo sapiens
2.7.1.67 50000
-
 x * 50000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.67
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.67 1.18
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.67 ? x * 50000, SDS-PAGE Homo sapiens
2.7.1.67 ? x * 45000, SDS-PAGE Homo sapiens
2.7.1.67 More two enzyme species a 45000 Da enzyme and a 50000 Da enzyme Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.67 0.0019
-
 Ca2+ pH 7.2, 37°C, 45000 Da enzyme Homo sapiens
2.7.1.67 0.0025
-
 Ca2+ pH 7.2, 37°C, 50000 Da enzyme Homo sapiens
2.7.1.67 0.08
-
 adenosine pH 7.2, 37°C, 45000 Da enzyme Homo sapiens
2.7.1.67 0.1
-
 adenosine pH 7.2, 37°C, 50000 Da enzyme Homo sapiens