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Literature summary extracted from

  • Kai, M.; White, G.L.; Hawthorne, J.N.
    The phosphatidylinositol kinase of rat brain (1966), Biochem. J., 101, 328-337.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.67 2-mercaptoethanol enhances activity Rattus norvegicus
2.7.1.67 3-Mercaptopropionic acid enhances activity Rattus norvegicus
2.7.1.67 cetyltrimethyl ammonium bromide weak stimulation Rattus norvegicus
2.7.1.67 Cutsum stimulates Rattus norvegicus
2.7.1.67 EDTA 2 mM, marked stimulation, even in presence of 30 mM Mg2+ Rattus norvegicus
2.7.1.67 GSH enhances activity Rattus norvegicus
2.7.1.67 additional information activity of the enzyme is dependent on SH groups Rattus norvegicus
2.7.1.67 sodium deoxycholate stimulates Rattus norvegicus
2.7.1.67 sodium taurocholate weak stimulation Rattus norvegicus
2.7.1.67 Triton X-100 stimulates Rattus norvegicus
2.7.1.67 Tween-20 weak stimulation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 Ca2+
-
 Rattus norvegicus
2.7.1.67 Cu2+ 0.25 mM CuCl2, complete inhibition Rattus norvegicus
2.7.1.67 F-
-
 Rattus norvegicus
2.7.1.67 K+
-
 Rattus norvegicus
2.7.1.67 Na+
-
 Rattus norvegicus
2.7.1.67 NaF 70% inhibition at 1 mM, complete inhibition at 10 mM Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.67 Mg2+ enzyme is activated by Mn2+ or Mg2+ Rattus norvegicus
2.7.1.67 Mn2+ enzyme is activated by Mg2+ or Mn2+ Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 brain
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
2.7.1.67 -20°C, brain homogenate in 0.32 M sucrose, stable for up to 6 d Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?