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Literature summary extracted from

  • Kundig, W.; Ghosh, S.; Roseman, S.
    The sialic acids. VII. N-acyl-D-mannosamine kinase from rat liver (1966), J. Biol. Chem., 241, 5619-5626.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.7.1.60 purified enzyme is unstable to ammonium sulfate precipitation or freezing and thawing Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.60 0.2
-
N-acetyl-D-mannosamine pH 8.1, 37°C Rattus norvegicus
2.7.1.60 1.2
-
N-glycolylmannosamine pH 8.1, 37°C Rattus norvegicus
2.7.1.60 2
-
ATP pH 8.1, 37°C Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.60 Mg2+ required for activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.60 ATP + N-acetyl-D-mannosamine Rattus norvegicus metabolic pathway between hexoses and sialic acids ADP + N-acetyl-D-mannosamine 6-phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.60 Rattus norvegicus
-
rat, albino
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.60
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.60 kidney
-
Rattus norvegicus
-
2.7.1.60 liver
-
Rattus norvegicus
-
2.7.1.60 additional information no enzymatic activity in brain, heart and muscle Rattus norvegicus
-
2.7.1.60 spleen
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.60 2.5
-
activity of fraction with N-glycolylmannosamine Rattus norvegicus
2.7.1.60 2.76
-
activity of fraction with N-glycolylmannosamine Rattus norvegicus
2.7.1.60 4
-
activity of fraction with N-acetylmannosamine Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.7.1.60 0°C, loses about 50% of its activity in 24 hours, stable for at least 1 week in presence of 0.01 M N-acylmannosamine Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.60 ATP + N-acetyl-D-mannosamine metabolic pathway between hexoses and sialic acids Rattus norvegicus ADP + N-acetyl-D-mannosamine 6-phosphate
-
?
2.7.1.60 ATP + N-acetyl-D-mannosamine
-
Rattus norvegicus ADP + N-acetyl-D-mannosamine-6-phosphate
-
?
2.7.1.60 ATP + N-glycolylmannosamine
-
Rattus norvegicus N-glycolylmannosamine-6-phosphate
-
?
2.7.1.60 additional information N-acetylglucosamine and N-glycolylglucosamine, N-acetylgalactosamine, mannosamine, glucosamine, galactosamine, mannose, galactose, fructose, glucose, glucose-1-phosphate and glucose-6-phosphate are inactive as substrates, the phosphoryl donor ATP cannot be replaced by GTP, UTP, CTP, TTP, dATP or phosphoenolpyruvate Rattus norvegicus ?
-
?