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Literature summary extracted from

  • Hinderlich, S.; Berger, M.; Schwarzkopf, M.; Effertz, K.; Reutter, W.
    Molecular cloning and characterization of murine and human N-acetylglucosamine kinase (2000), Eur. J. Biochem., 267, 3301-3308.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.59
-
Homo sapiens
2.7.1.59 functionally expressed in Escherichia coli BL21, active enzyme, high rate of protein expression in transfected cells, inclusion bodies Mus musculus
2.7.1.60
-
Homo sapiens
2.7.1.60 cloned and functionally expressed in Escherichia coli BL21 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.59 N-acetyl-D-glucosamine inhibition of activity with N-acetyl-D-mannosamine Mus musculus
2.7.1.59 N-acetyl-D-mannosamine no inhibition of activity with N-acetyl-D-glucosamine Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.59 41000
-
SDS-PAGE, from E. coli Mus musculus
2.7.1.59 373000
-
calculated from DNA sequence Mus musculus
2.7.1.59 374000
-
calculated from DNA sequence Homo sapiens
2.7.1.60 37300
-
amino acid sequence, predicted from an open reading frame Mus musculus
2.7.1.60 37400
-
amino acid sequence, predicted from an open reading frame Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.59 ATP + N-acetyl-D-glucosamine Mus musculus
-
ADP + N-acetyl-D-glucosamine 6-phosphate
-
?
2.7.1.59 ATP + N-acetyl-D-glucosamine Homo sapiens
-
ADP + N-acetyl-D-glucosamine 6-phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.59 Homo sapiens Q9UJ70
-
-
2.7.1.59 Mus musculus Q9QZ08 sequence with additional 92 bp sequence found in lung, EMBL: AF242911
-
2.7.1.60 Homo sapiens
-
-
-
2.7.1.60 Mus musculus
-
mouse
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.59 from E. coli Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.59 brain
-
Mus musculus
-
2.7.1.59 brain
-
Homo sapiens
-
2.7.1.59 heart
-
Mus musculus
-
2.7.1.59 heart
-
Homo sapiens
-
2.7.1.59 kidney
-
Mus musculus
-
2.7.1.59 kidney
-
Homo sapiens
-
2.7.1.59 liver
-
Mus musculus
-
2.7.1.59 liver
-
Homo sapiens
-
2.7.1.59 lung
-
Mus musculus
-
2.7.1.59 lung
-
Homo sapiens
-
2.7.1.59 additional information present in cancer cell lines Homo sapiens
-
2.7.1.59 muscle
-
Mus musculus
-
2.7.1.59 muscle
-
Homo sapiens
-
2.7.1.59 spleen
-
Mus musculus
-
2.7.1.59 spleen
-
Homo sapiens
-
2.7.1.59 testis very high activity Mus musculus
-
2.7.1.59 testis very high activity Homo sapiens
-
2.7.1.60 testis
-
Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.59 0.137
-
enzyme expressed in E. coli, 37°C, pH 7.5 Mus musculus
2.7.1.59 25
-
purified enzyme from E. coli, 37°C, pH 7.5 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.59 ATP + N-acetyl-D-glucosamine
-
Mus musculus ADP + N-acetyl-D-glucosamine 6-phosphate
-
?
2.7.1.59 ATP + N-acetyl-D-glucosamine
-
Homo sapiens ADP + N-acetyl-D-glucosamine 6-phosphate
-
?
2.7.1.59 ATP + N-acetyl-D-mannosamine recombinant enzyme, same rate as with N-acetyl-D-glucosamine Mus musculus ADP + N-acetyl-D-mannosamine 6-phosphate
-
?
2.7.1.59 additional information D-fructose, D-mannose, D-maltose, D-galactose, N-acetyl-D-galactosamine, ribose, fucose do not serve as substrates Mus musculus ?
-
?
2.7.1.60 additional information displays N-acetylglucosamine kinase activity as well as N-acetylmannosamine kinase activity Mus musculus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.60 EC 2.7.1.59/EC 2.7.1.60 bifunctional, N-acetylglucosamine kinase and N-acetylmannosamine kinase activity Mus musculus