EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.59 | 5,5'-dithiobis(2-nitrobenzoic acid) | substrates partially protect against inactivation | Rattus norvegicus | |
2.7.1.59 | arsenite/2,3-dimercaptopropanol | substrates partially protect against inactivation | Rattus norvegicus | |
2.7.1.59 | Diamide | substrates partially protect against inactivation | Rattus norvegicus | |
2.7.1.59 | iodoacetamide | substrates partially protect against inactivation | Rattus norvegicus | |
2.7.1.59 | N-ethylmaleimide | substrates partially protect against inactivation | Rattus norvegicus | |
2.7.1.59 | Periodate | substrates partially protect against inactivation | Rattus norvegicus | |
2.7.1.60 | 5,5'-dithiobis(2-nitrobenzoic acid) | - |
Rattus norvegicus | |
2.7.1.60 | arsenite/2,3-dimercaptopropanol | - |
Rattus norvegicus | |
2.7.1.60 | Diamide | - |
Rattus norvegicus | |
2.7.1.60 | iodoacetamide | - |
Rattus norvegicus | |
2.7.1.60 | N-ethylmaleimide | - |
Rattus norvegicus | |
2.7.1.60 | Periodate | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.59 | 0.05 | - |
N-acetyl-D-glucosamine | 37°C, pH 7.5 | Rattus norvegicus | |
2.7.1.59 | 1 | - |
N-acetyl-D-mannosamine | 37°C, pH 7.5 | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.59 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.1.59 | 39000 | - |
identification of 90000 Da band, found to be another protein | Rattus norvegicus |
2.7.1.59 | 39000 | - |
SDS-PAGE, second band at 90000 Da shows no activity | Rattus norvegicus |
2.7.1.59 | 80000 | - |
gel filtration | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.59 | ATP + N-acetyl-D-glucosamine | Rattus norvegicus | - |
ADP + N-acetyl-D-glucosamine 6-phosphate | - |
? | |
2.7.1.60 | ATP + N-acetyl-D-mannosamine | Rattus norvegicus | involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis | ADP + N-acetyl-D-mannosamine 6-phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.59 | Rattus norvegicus | - |
- |
- |
2.7.1.60 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.59 | - |
Rattus norvegicus |
2.7.1.60 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.59 | liver | - |
Rattus norvegicus | - |
2.7.1.60 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.1.59 | 52.4 | - |
purified enzyme, 37°C, pH 7.5 | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.59 | ATP + N-acetyl-D-glucosamine | - |
Rattus norvegicus | ADP + N-acetyl-D-glucosamine 6-phosphate | - |
? | |
2.7.1.59 | ATP + N-acetyl-D-mannosamine | - |
Rattus norvegicus | ADP + N-acetyl-D-mannosamine 6-phosphate | - |
? | |
2.7.1.60 | ATP + N-acetyl-D-mannosamine | involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis | Rattus norvegicus | ADP + N-acetyl-D-mannosamine 6-phosphate | - |
? | |
2.7.1.60 | ATP + N-acetyl-D-mannosamine | - |
Rattus norvegicus | ADP + N-acetyl-D-mannosamine-6-phosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.1.59 | dimer | 2 * 39000, SDS-PAGE, gel filtration | Rattus norvegicus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.60 | EC 5.1.3.14/EC 2.7.1.60 | - |
Rattus norvegicus |
2.7.1.60 | UDP-GlcNAc-epimerase/ManNAc kinase | - |
Rattus norvegicus |