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Literature summary extracted from

  • Allen, M.B.; Walker, D.G.
    Kinetic characterization of N-acetyl-D-glucosamine kinase from rat liver and kidney (1980), Biochem. J., 185, 577-582.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.59 ADP
-
Rattus norvegicus
2.7.1.59 N-acetyl-D-glucosamine inhibits phosphorylation of D-glucose Rattus norvegicus
2.7.1.59 N-acetyl-D-mannosamine inhibits phosphorylation of D-glucose Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.59 0.04
-
N-acetyl-D-glucosamine enzyme from kidney, 32°C, pH 7.5 Rattus norvegicus
2.7.1.59 0.06
-
N-acetyl-D-glucosamine enzyme from liver, 32°C, pH 7.5 Rattus norvegicus
2.7.1.59 0.1
-
ATP enzyme from kidney with N-acetyl-D-glucosamine as substrate, 32°C, pH 7.5 Rattus norvegicus
2.7.1.59 0.1
-
ATP ATP in form of MgATP2- Rattus norvegicus
2.7.1.59 0.23
-
ATP enzyme from liver with N-acetyl-D-glucosamine as substrate, 32°C, pH 7.5 Rattus norvegicus
2.7.1.59 0.23
-
ATP ATP in form of MgATP2- Rattus norvegicus
2.7.1.59 0.95
-
N-acetyl-D-mannosamine enzyme from liver, 32°C, pH 7.5 Rattus norvegicus
2.7.1.59 1
-
N-acetyl-D-mannosamine enzyme from kidney, 32°C, pH 7.5 Rattus norvegicus
2.7.1.59 410
-
D-glucose enzyme from kidney, 32°C, pH 7.5 Rattus norvegicus
2.7.1.59 600
-
D-glucose enzyme from liver, 32°C, pH 7.5 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.59 soluble
-
Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.59 Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.59 ATP + N-acetyl-D-glucosamine Rattus norvegicus
-
ADP + N-acetyl-D-glucosamine 6-phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.59 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.59 from liver and kidney Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.59 kidney
-
Rattus norvegicus
-
2.7.1.59 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.59 ATP + D-glucose
-
Rattus norvegicus ADP + D-glucose 6-phosphate
-
?
2.7.1.59 ATP + N-acetyl-D-glucosamine
-
Rattus norvegicus ADP + N-acetyl-D-glucosamine 6-phosphate
-
?
2.7.1.59 ATP + N-acetyl-D-mannosamine roughly 50% of activity Rattus norvegicus ADP + N-acetyl-D-mannosamine 6-phosphate
-
?

Subunits

EC Number Subunits Comment Organism
2.7.1.59 dimer postulated due to kinetic data Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.59 7.4
-
-
Rattus norvegicus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.7.1.59 6.2 8.5 relatively stable at pH 6.2, rapid loss of activity above pH 8.5 Rattus norvegicus