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Literature summary extracted from

  • Orengo, A.
    Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor (1969), J. Biol. Chem., 244, 2204-2209.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.48 CTP inhibition is partially lost upon ageing of the enzyme and CTP becomes effective as a phosphate donor Rattus norvegicus
2.7.1.48 UTP
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.48 Mg2+ required for full activity Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.48 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.48 streptomycin, ammonium sulfate, calcium phosphate, Sephadex G-200 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.48 ATP + uridine = ADP + UMP ping-pong mechanism Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.48 Novikoff ascites tumor cell
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.48 0.88
-
-
 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.7.1.48 -20°C, 50% glycerol, at least 6 months, no loss of activity Rattus norvegicus
2.7.1.48 4°C, at least 1 month, no loss of activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.48 ATP + uridine
-
 Rattus norvegicus ADP + UMP
-
 ?
2.7.1.48 dATP + uridine
-
 Rattus norvegicus dADP + UMP
-
 ?
2.7.1.48 dGTP + uridine
-
 Rattus norvegicus dGDP + UMP
-
 ?
2.7.1.48 dUTP + uridine
-
 Rattus norvegicus dUDP + UMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.48 uridine-cytidine kinase
-
 Rattus norvegicus