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Literature summary extracted from

  • Sidbury, J.B.; Rosenberg, L.L.; Najjar, V.A.
    Muscle glucose-1-phosphate transphosphorylase (1956), J. Biol. Chem., 222, 89-96.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.41 additional information forward reaction is not activated by ATP, cysteine, histidine, adenylic acid or phosphate Oryctolagus cuniculus

General Stability

EC Number General Stability Organism
2.7.1.41 stable to 3-4 h dialysis against distilled water, prolonged or repeated dialysis inactivates Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.41 ATP inhibits forward reaction above 2 mM Oryctolagus cuniculus
2.7.1.41 Cu2+ weak, 0.1 mM Oryctolagus cuniculus
2.7.1.41 Mg2+ inhibits reverse reaction at 0.5 mM, forward reaction: activation Oryctolagus cuniculus
2.7.1.41 Mn2+ inhibits forward reaction above 0.5 mM Oryctolagus cuniculus
2.7.1.41 additional information not inhibited by 8 mM fluoride, cysteine, histidine, adenylic acid or phosphate Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.41 Mg2+ activation of forward reaction, optimal concentration: 1 mM, inhibition of reverse reaction, Mg2+ forms a complex with the product glucose-1,6-bisphosphate Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.41 Escherichia coli
-
-
-
2.7.1.41 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.41 partial, not separated from phosphoglucomutase Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.41 skeletal muscle muscles of back and hind legs Oryctolagus cuniculus
-

Storage Stability

EC Number Storage Stability Organism
2.7.1.41 6°C, within 1 week, inactivation Oryctolagus cuniculus
2.7.1.41 frozen, partially purified preparation, at least 4 weeks, stable Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.41 D-glucose 1-phosphate + D-glucose 1-phosphate
-
 Escherichia coli D-glucose + D-glucose 1,6-bisphosphate
-
 ?
2.7.1.41 D-glucose 1-phosphate + D-glucose 1-phosphate
-
 Oryctolagus cuniculus D-glucose + D-glucose 1,6-bisphosphate
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.41 30
-
-
 Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.41 7.6
-
 forward reaction, in the presence of Mg2+ Oryctolagus cuniculus