Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Soong Lee, C.; O'Sullivan, W.J.O.
    Phosphorothioate analogues of adenosine triphosphate as substrates of the mevalonate kinase reaction (1984), Biochim. Biophys. Acta, 787, 131-137.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.36 0.05
-
 Co-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.058
-
 Zn-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.059
-
 Cd-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.075
-
 Mn-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.09
-
 Co-adenosine 5'-O-(1-thio-(R)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.091
-
 Ni-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.1
-
 Co-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.12
-
 Mg-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.12
-
 Zn-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.14
-
 Ca-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.14
-
 Ni-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.16
-
 Mg-adenosine 5'-O-(1-thio-(S)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.2
-
 Co-adenosine 5'-O-(1-thio-(S)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.22
-
 Cd-adenosine 5'-O-(1-thio-(R)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.28
-
 Cd-adenosine 5'-O-(1-thio-(S)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.29
-
 Mn-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.46
-
 Cd-adenosine 5'-O-(2-thio-(S)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.59
-
 Mg-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.6
-
 Ca-adenosine 5'-O-(2-thio-(R)-triphosphate) pH 8.0 Sus scrofa
2.7.1.36 0.69
-
 ATP pH 8.0 Sus scrofa
2.7.1.36 2.44
-
 Mg-adenosine 5'-O-(1-thio-(R)-triphosphate) pH 8.0 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.36 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.36 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.36 adenosine 5'-O-(1-thio-triphosphate) + mevalonate 40% of activity with ATP in the presence of 2 mM Mg2+ Sus scrofa adenosine 5'-O-(1-thio-diphosphate) + 5-phosphomevalonate
-
 ?
2.7.1.36 adenosine 5'-O-(2-thio-triphosphate) + mevalonate 54% of activity with ATP in the presence of 2 mM Mg2+ Sus scrofa adenosine 5'-O-(2-thio-diphosphate) + 5-phosphomevalonate
-
 ?
2.7.1.36 adenosine 5'-O-(3-thio-triphosphate) + mevalonate 4% of activity with ATP in the presence of 2 mM Mg2+ Sus scrofa adenosine 5'-O-(3-thio-diphosphate) + 5-phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate ATPgammaS, ATPalphaS and ATPbetaS can act as substrates in presence of different activating divalent metal cations, in the presence of Mg2+ the R diastereomers of both ATPalphaS and ATPbetaS are the preferred substrates, in presence of Cd2+ the S diastereomers are more active Sus scrofa ADP + phosphomevalonate
-
 ?
2.7.1.36 Ca-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Ca-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Cd-adenosine 5'-O-(1-thio-(R)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Cd-adenosine 5'-O-(1-thio-(S)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Cd-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Cd-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Co-adenosine 5'-O-(1-thio-(R)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Co-adenosine 5'-O-(1-thio-(S)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Co-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Co-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Mg-adenosine 5'-O-(1-thio-(R)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Mg-adenosine 5'-O-(1-thio-(S)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Mg-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Mg-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Mn-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Mn-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Ni-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Ni-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Zn-adenosine 5'-O-(2-thio-(R)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?
2.7.1.36 Zn-adenosine 5'-O-(2-thio-(S)-triphosphate) + (R)-mevalonate
-
 Sus scrofa ?
-
 ?