EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.36 | UTP | stimulation of ATP utilization | Saccharomyces cerevisiae |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.36 | p-chloromercuribenzoate | 0.1 mM, 83% inhibition, completely reversed by reduced glutathione | Saccharomyces cerevisiae |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.36 | Ca2+ | can partially replace Mn2+ in activation | Saccharomyces cerevisiae | |
2.7.1.36 | Ca2+ | at 5 mM 10% of the activity with Mn2+ | Saccharomyces cerevisiae | |
2.7.1.36 | Co2+ | can partially replace Mn2+ in activation | Saccharomyces cerevisiae | |
2.7.1.36 | Co2+ | approx. 15% of the activity with Mn2+ at 5 mM | Saccharomyces cerevisiae | |
2.7.1.36 | Fe2+ | can partially replace Mn2+ in activation | Saccharomyces cerevisiae | |
2.7.1.36 | Fe2+ | at 5 mM about 10% of the activity with Mn2+ | Saccharomyces cerevisiae | |
2.7.1.36 | Mg2+ | Mg2+ becomes increasingly active at higher concentrations and at sufficiently high concentrations the most active metal ion | Saccharomyces cerevisiae | |
2.7.1.36 | Mn2+ | divalent cation required for activity | Saccharomyces cerevisiae | |
2.7.1.36 | Mn2+ | higher activation than with Mg2+ at concentrations below approx. 0.008 mM, lower activation than with Mg2+ above | Saccharomyces cerevisiae | |
2.7.1.36 | Zn2+ | can partially replace Mn2+ in activation | Saccharomyces cerevisiae | |
2.7.1.36 | Zn2+ | at 5 mM about 30% of the activity of Mn2+ | Saccharomyces cerevisiae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.36 | Saccharomyces cerevisiae | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.36 | protamine sulfate, ammonium sulfate, acid treatment at pH 5.0, ammonium sulfate | Saccharomyces cerevisiae |
EC Number | Storage Stability | Organism |
---|---|---|
2.7.1.36 | -10°C, several months, no loss of activity | Saccharomyces cerevisiae |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.36 | ATP + mevalonate | no activity with ADP | Saccharomyces cerevisiae | ADP + phosphomevalonate | - |
? | |
2.7.1.36 | CTP + mevalonate | - |
Saccharomyces cerevisiae | CDP + phosphomevalonate | - |
? | |
2.7.1.36 | GTP + mevalonate | - |
Saccharomyces cerevisiae | GDP + phosphomevalonate | - |
? | |
2.7.1.36 | UTP + mevalonate | - |
Saccharomyces cerevisiae | UDP + phosphomevalonate | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.36 | 6.4 | 6.7 | - |
Saccharomyces cerevisiae |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.36 | 5 | 9 | more than 50% of maximal activity at pH 5.0 and pH 9.0 | Saccharomyces cerevisiae |