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Literature summary extracted from

  • Kwok, F.; Churchich, J.E.
    Brain pyridoxal kinase. Purification, substrate specificities, and sensitized photodestruction of an essential histidine (1979), J. Biol. Chem., 254, 6489-6495.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.35 4-deoxypyridoxine competitive with respect to pyridoxal Sus scrofa
2.7.1.35 5-dimethylaminonaphthalene-1-sulfonyl-4-aminobutyrate competitive with respect to pyridoxal Sus scrofa
2.7.1.35 pyridoxaloxime competitive with respect to pyridoxal Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.35 0.012
-
 ATP pH 6.0, 37°C Sus scrofa
2.7.1.35 0.017
-
 pyridoxine pH 6.0, 37°C Sus scrofa
2.7.1.35 0.025
-
 pyridoxal pH 6, 37°C Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.35 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.35
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.35 brain
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.35 0.0713
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.35 ATP + pyridoxal
-
 Sus scrofa ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxamine not a substrate of the purified enzyme Sus scrofa ADP + pyridoxamine 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxine 46% of the activity with pyridoxal Sus scrofa ADP + pyridoxine 5'-phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.35 6
-
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.35 0.001
-
 4-deoxypyridoxine pH 6.0, 37°C Sus scrofa
2.7.1.35 0.002
-
 5-dimethylaminonaphthalene-1-sulfonyl-4-aminobutyrate pH 8.0, 37°C Sus scrofa
2.7.1.35 0.002
-
 pyridoxaloxime pH 6.0, 37°C Sus scrofa