Literature summary extracted from

Karawya, E.; Mostafa, M.H.; Osman, N.
The kinetic mechanism of inhibition of liver pyridoxal kinase with tryptophan metabolites (1981), Biochim. Biophys. Acta, 657, 153-158.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.1.35	3-hydroxyanthranilic acid	IC50: 0.12 mM	Ovis aries
2.7.1.35	3-hydroxykynurenine	IC50: 0.1 mM	Ovis aries
2.7.1.35	quinolinic acid	IC50: 0.42 mM	Ovis aries
2.7.1.35	xanthurenic acid	IC50: 0.36 mM	Ovis aries

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.35	Ovis aries	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
2.7.1.35	-	Ovis aries

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.1.35	liver	-	Ovis aries	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.35	ATP + pyridoxal	-	Ovis aries	ADP + pyridoxal 5'-phosphate	-	?

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
2.7.1.35	0.1	-	IC50: 0.1 mM	Ovis aries	3-hydroxykynurenine
2.7.1.35	0.12	-	IC50: 0.12 mM	Ovis aries	3-hydroxyanthranilic acid
2.7.1.35	0.36	-	IC50: 0.36 mM	Ovis aries	xanthurenic acid
2.7.1.35	0.42	-	IC50: 0.42 mM	Ovis aries	quinolinic acid

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Release 2023.1 (January 2023)