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Literature summary extracted from

  • Chern, C.J.; Beutler, E.
    Purification and characterization of human erythrocyte pyridoxine kinase (1975), Clin. Chim. Acta, 61, 353-365.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.35 NH4+ slightly less effective in activation than K+ Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.35 4-deoxypyridoxine
-
 Homo sapiens
2.7.1.35 Na+
-
 Homo sapiens
2.7.1.35 pyridoxal
-
 Homo sapiens
2.7.1.35 pyridoxamine
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.35 0.0057
-
 pyridoxine
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.35 Co2+ cations activate in decreasing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens
2.7.1.35 Cu2+ cations activate in decreasing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens
2.7.1.35 Fe2+ cations activate in decreaseing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens
2.7.1.35 K+ most effective activator of the monovalent cations Homo sapiens
2.7.1.35 Mg2+ cations activate in decreasing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens
2.7.1.35 Mn2+ cations activate in decreasing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens
2.7.1.35 Ni2+ cations activate in decreasing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens
2.7.1.35 Zn2+ cations activate in decreasing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.35 65000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.35 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.35
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.35 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.35 ATP + pyridoxal
-
 Homo sapiens ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxine
-
 Homo sapiens ADP + pyridoxine 5'-phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.35 8.5
-
-
 Homo sapiens