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Literature summary extracted from

  • McCormick, D.B.; Gregory, M.E.; Snell, E.E.
    Pyridoxal phosphokinases. I. Assay, distribution, purification, and properties (1961), J. Biol. Chem., 236, 2076-2084.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.35 AMP
-
 Rattus norvegicus
2.7.1.35 K+ at high concentrations Bos taurus
2.7.1.35 Li+ at high concentrations Bos taurus
2.7.1.35 Na+ at high concentrations Bos taurus
2.7.1.35 Na+
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.35 soluble
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.35 Co2+
-
 Homo sapiens
2.7.1.35 Co2+ 0.2 mM, partial activation Saccharomyces cerevisiae
2.7.1.35 Cu2+
-
 Homo sapiens
2.7.1.35 Cu2+ 0.2 mM, partial activation Meleagris gallopavo
2.7.1.35 K+
-
 Homo sapiens
2.7.1.35 K+ activates in presence of optimal concentrations of Zn2+ Bos taurus
2.7.1.35 Mg2+
-
 Homo sapiens
2.7.1.35 Mg2+ 0.2 mM, activates Meleagris gallopavo
2.7.1.35 Mg2+ 0.2 mM, activates Rattus norvegicus
2.7.1.35 Mn2+
-
 Homo sapiens
2.7.1.35 Mn2+ 0.2 mM, partial activation Meleagris gallopavo
2.7.1.35 Mn2+ 0.2 mM, partial activation Rattus norvegicus
2.7.1.35 Mn2+ 0.2 mM, partial activation Saccharomyces cerevisiae
2.7.1.35 Ni2+
-
 Homo sapiens
2.7.1.35 Ni2+ 0.2 mM, partial activation Saccharomyces cerevisiae
2.7.1.35 Zn2+
-
 Homo sapiens
2.7.1.35 Zn2+ 0.2 mM, activates Meleagris gallopavo
2.7.1.35 Zn2+ 0.2 mM, activates Rattus norvegicus
2.7.1.35 Zn2+ 0.2 mM, activates Saccharomyces cerevisiae
2.7.1.35 Zn2+ half-maximal activation at 0.01 mM Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.35 Bos taurus
-
-
-
2.7.1.35 Enterococcus faecalis
-
-
-
2.7.1.35 Homo sapiens
-
-
-
2.7.1.35 Lacticaseibacillus casei
-
-
-
2.7.1.35 Lactobacillus delbrueckii subsp. bulgaricus
-
-
-
2.7.1.35 Meleagris gallopavo
-
-
-
2.7.1.35 Mus musculus
-
-
-
2.7.1.35 Neurospora crassa
-
-
-
2.7.1.35 Oryctolagus cuniculus
-
-
-
2.7.1.35 Rattus norvegicus
-
-
-
2.7.1.35 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.35
-
 Saccharomyces cerevisiae
2.7.1.35
-
 Enterococcus faecalis
2.7.1.35
-
 Lacticaseibacillus casei

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.35 brain
-
 Meleagris gallopavo
-
2.7.1.35 brain
-
 Homo sapiens
-
2.7.1.35 brain
-
 Rattus norvegicus
-
2.7.1.35 brain
-
 Bos taurus
-
2.7.1.35 kidney
-
 Rattus norvegicus
-
2.7.1.35 liver
-
 Rattus norvegicus
-
2.7.1.35 muscle weak activity Rattus norvegicus
-
2.7.1.35 mycelium
-
 Saccharomyces cerevisiae
-
2.7.1.35 spleen
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.35 0.00135
-
-
 Lacticaseibacillus casei
2.7.1.35 0.0036
-
-
 Enterococcus faecalis
2.7.1.35 0.004
-
 brain enzyme Rattus norvegicus
2.7.1.35 0.0125
-
-
 Bos taurus
2.7.1.35 0.0125
-
 liver enzyme Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.35 ATP + pyridoxal
-
 Meleagris gallopavo ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Mus musculus ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Homo sapiens ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Rattus norvegicus ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Saccharomyces cerevisiae ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Bos taurus ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Oryctolagus cuniculus ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Neurospora crassa ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Enterococcus faecalis ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Lacticaseibacillus casei ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Lactobacillus delbrueckii subsp. bulgaricus ADP + pyridoxal 5'-phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.35 40
-
 Zn2+ as activating anion Homo sapiens
2.7.1.35 50
-
 Mg2+ as activating anion Homo sapiens
2.7.1.35 55
-
-
 Rattus norvegicus
2.7.1.35 55
-
-
 Lacticaseibacillus casei
2.7.1.35 63
-
-
 Enterococcus faecalis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.35 4.5
-
-
 Lactobacillus delbrueckii subsp. bulgaricus
2.7.1.35 5
-
-
 Lacticaseibacillus casei
2.7.1.35 5.2
-
-
 Enterococcus faecalis
2.7.1.35 5.7
-
-
 Rattus norvegicus
2.7.1.35 5.8
-
-
 Saccharomyces cerevisiae
2.7.1.35 6.5
-
-
 Saccharomyces cerevisiae
2.7.1.35 6.8
-
-
 Saccharomyces cerevisiae

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.35 4.7 5.3 pH 4.7: about 60% of maximal activity, pH 5.3: about 40% of maximal activity Lacticaseibacillus casei
2.7.1.35 5 5.7 pH 5.0: about 90% of maximal activity, pH 5.7: about 45% of maximal activity Enterococcus faecalis
2.7.1.35 6 7 pH 6.0: about 50% of maximal activity, pH 7.0: about 50% of maximal activity Neurospora crassa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.35 0.06
-
 AMP
-
 Rattus norvegicus