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Literature summary extracted from

  • Ishidate, K.
    Choline/ethanolamine kinase from mammalian tissues (1997), Biochim. Biophys. Acta, 1348, 70-78.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.32 overview Homo sapiens
2.7.1.32 overview Rattus norvegicus
2.7.1.82 overview Homo sapiens
2.7.1.82 overview Rattus norvegicus
2.7.1.82 overview Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.82 0.02
-
choline
-
Saccharomyces cerevisiae
2.7.1.82 10
-
ethanolamine
-
Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.82 42000
-
2 * 42000, SDS-PAGE Rattus norvegicus
2.7.1.82 44000
-
2 * 44000, SDS-PAGE Homo sapiens
2.7.1.82 87000
-
gel filtration Homo sapiens
2.7.1.82 90000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.32 ATP + choline Homo sapiens initial enzyme of the CDP-choline pathway and the CDP-ethanolamine pathway ADP + O-phosphocholine
-
?
2.7.1.32 ATP + choline Rattus norvegicus initial enzyme of the CDP-choline pathway and the CDP-ethanolamine pathway ADP + O-phosphocholine
-
?
2.7.1.32 ATP + choline Homo sapiens choline pathway or CDP-ethanolamine pathway is so-called Kennedy pathway ADP + O-phosphocholine
-
?
2.7.1.32 ATP + choline Rattus norvegicus choline pathway or CDP-ethanolamine pathway is so-called Kennedy pathway ADP + O-phosphocholine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.32 Homo sapiens
-
-
-
2.7.1.32 Rattus norvegicus
-
-
-
2.7.1.82 Homo sapiens
-
-
-
2.7.1.82 Rattus norvegicus
-
-
-
2.7.1.82 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.32 overview Homo sapiens
2.7.1.32 overview Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.82 ATP + ethanolamine = ADP + O-phosphoethanolamine major part of choline kinase and ethanolamine kinase activities are catalyzed by the same enzyme Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.82 kidney
-
Rattus norvegicus
-
2.7.1.82 liver
-
Homo sapiens
-
2.7.1.82 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.32 ATP + choline initial enzyme of the CDP-choline pathway and the CDP-ethanolamine pathway Homo sapiens ADP + O-phosphocholine
-
?
2.7.1.32 ATP + choline initial enzyme of the CDP-choline pathway and the CDP-ethanolamine pathway Rattus norvegicus ADP + O-phosphocholine
-
?
2.7.1.32 ATP + choline choline pathway or CDP-ethanolamine pathway is so-called Kennedy pathway Homo sapiens ADP + O-phosphocholine
-
?
2.7.1.32 ATP + choline choline pathway or CDP-ethanolamine pathway is so-called Kennedy pathway Rattus norvegicus ADP + O-phosphocholine
-
?
2.7.1.32 additional information specificity overview Homo sapiens ?
-
?
2.7.1.32 additional information specificity overview Rattus norvegicus ?
-
?
2.7.1.82 ATP + choline
-
Saccharomyces cerevisiae ADP + ?
-
?
2.7.1.82 ATP + ethanolamine
-
Saccharomyces cerevisiae ADP + O-phosphoethanolamine
-
?

Subunits

EC Number Subunits Comment Organism
2.7.1.82 dimer 2 * 44000, SDS-PAGE Homo sapiens
2.7.1.82 dimer 2 * 42000, SDS-PAGE Rattus norvegicus