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Literature summary extracted from

  • Weinhold, P.A.; Rethy, V.B.
    The separation, purification, and characterization of ethanolamine kinase and choline kinase from rat liver (1974), Biochemistry, 13, 5135-5141.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.82 choline ethanolamine kinase I not inhibited, ethanolamine kinase II strongly inhibited Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.32 0.03
-
choline
-
Rattus norvegicus
2.7.1.32 3.7
-
N-Monomethylethanolamine cosubstrate ATP Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.82 Ca2+ can substitute for Mg2+ Rattus norvegicus
2.7.1.82 Mg2+ ethanolamine kinase I: uses MgATP2- as substrate but also has an additional requirement for Mg2+ Rattus norvegicus
2.7.1.82 Mg2+ maximal activation at 16 mM MgATP2-, inhibition above Rattus norvegicus
2.7.1.82 Mg2+ Km MgATP2-: 14 mM Rattus norvegicus
2.7.1.82 Mg2+ ethanolamine kinase II: requires MgATP2- as substrate, maximal activation with 10 mM of Mg2+ and ATP Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.82 36000
-
ethanolamine kinase I, gel filtration Rattus norvegicus
2.7.1.82 160000
-
ethanolamine kinase II, gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.32 Rattus norvegicus
-
-
-
2.7.1.82 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.82 ethanolamine kinase I and II Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.32 ATP + choline = ADP + phosphocholine ethanolamine kinase II and choline kinase do not use a common active site Rattus norvegicus
2.7.1.82 ATP + ethanolamine = ADP + O-phosphoethanolamine ethanolamine kinase II and choline kinase do not use a common active site Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.82 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.32 0.169
-
-
Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.7.1.82 -20°C, 0.02 M phosphate buffer, pH 7.0, 2.9 mM DTT, protein concentration 1.0 mg/ml, ethanolamine kinase I, 2 days, 40% loss of activity Rattus norvegicus
2.7.1.82 4°C, 1 week, ethanolamine kinase I, 50% loss of activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.32 ATP + choline
-
Rattus norvegicus ADP + O-phosphocholine
-
?
2.7.1.82 ATP + ethanolamine
-
Rattus norvegicus ADP + O-phosphoethanolamine
-
?
2.7.1.82 choline + ATP ethanolamine kinase II, not ethanolamine kinase I Rattus norvegicus ADP + O-phosphocholine
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.82 More cf. EC 2.7.1.32 Rattus norvegicus
2.7.1.82 More ethanolamine kinase II and choline kinase do not use a common active site Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.32 8
-
-
Rattus norvegicus
2.7.1.82 7.5 8.5 ethanolamine kinase I Rattus norvegicus
2.7.1.82 8 9.5 ethanolamine kinase II Rattus norvegicus