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Literature summary extracted from

  • Williams, M.B.; Jones, H.P.
    Calmodulin-dependent NAD kinase of human neutrophils (1985), Arch. Biochem. Biophys., 237, 80-87.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.23 Calmodulin calmodulin-dependent enzyme is stimulated 3.5fold by addition of calmodulin in presence of Ca2+ Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.23 Trifluoperazine inhibits stimulation by calmodulin Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.23 0.6
-
 NAD+
-
 Homo sapiens
2.7.1.23 0.9
-
 ATP
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.23 Ca2+ half-maximal activity at free calcium of approximately 0.0004 mM Homo sapiens
2.7.1.23 Mg2+ activity is strictly dependent on Mg2+. Maximal activity above 5 mM Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.23 169000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.23 Homo sapiens O95544
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.23 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.23 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.23 ATP + NAD+
-
 Homo sapiens ADP + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.23 7 9.5
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.23 NAD+
-
 Homo sapiens