Data extracted from this reference:
Cloned(Commentary)
2.7.1.21
TK2
Homo sapiens
Engineering
2.7.1.21
H121N
similar subunit structure to wild-type enzyme, decreased enzyme activity
Homo sapiens
2.7.1.21
I212N
similar subunit structure to wild-type enzyme, less than 1% activity compared to wild-type
Homo sapiens
Inhibitors
2.7.1.21
dCTP
Homo sapiens
2.7.1.21
deoxcytidine
Homo sapiens
2.7.1.21
dTTP
Homo sapiens
2.7.1.21
thymidine
Homo sapiens
KM Value [mM]
2.7.1.21
0.0057
thymidine
H121N mutant, pH 7.6
Homo sapiens
2.7.1.21
0.011
deoxycytidine
wild-type and H121N mutant, pH 7.6
Homo sapiens
2.7.1.21
0.013
thymidine
wild-type, pH 7.6
Homo sapiens
2.7.1.21
0.018
thymidine
I212 mutant, pH 7.6
Homo sapiens
2.7.1.21
0.025
ATP
wild-type, thymidine as substrate, pH 7.6
Homo sapiens
2.7.1.21
0.037
ATP
wild-type, deoxycytidine as substrate, pH 7.6
Homo sapiens
2.7.1.21
0.059
ATP
I212 mutant, deoxycytidine as substrate, pH 7.6
Homo sapiens
2.7.1.21
0.08
ATP
H121N mutant, thymidine as substrate, pH 7.6
Homo sapiens
2.7.1.21
0.095
ATP
I212 mutant, thymidine as substrate, pH 7.6
Homo sapiens
2.7.1.21
0.162
ATP
H121N mutant, deoxycytidine as substrate, pH 7.6
Homo sapiens
2.7.1.21
0.568
deoxycytidine
I212 mutant, pH 7.6
Homo sapiens
Localization
2.7.1.21
mitochondrion
Homo sapiens
5739
Organism
2.7.1.21
Homo sapiens
O00142
Substrates and Products (Substrate)
2.7.1.21
ATP + 2'-deoxycytidine
641150
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
Ki Value [mM]
2.7.1.21
0.00036
dCTP
H121N mutant, pH 7.6, competitive with thymidine as substrate
Homo sapiens
2.7.1.21
0.00079
dCTP
wild-type enzyme, pH 7.6, competitive with thymidine as substrate
Homo sapiens
2.7.1.21
0.00087
dCTP
wild-type enzyme, pH 7.6, competitive with deoxycytidine as substrate
Homo sapiens
2.7.1.21
0.00089
dCTP
H121N mutant, pH 7.6, competitive with deoxycytidine as substrate
Homo sapiens
2.7.1.21
0.00089
dTTP
H121N mutant, pH 7.6, competitive with thymidine as substrate
Homo sapiens
2.7.1.21
0.002
dTTP
wild-type enzyme, pH 7.6, competitive with thymidine as substrate
Homo sapiens
2.7.1.21
0.0025
dTTP
wild-type and H121N mutant, pH 7.6, non-competitive with deoxycytidine as substrate
Homo sapiens
2.7.1.21
0.0036
thymidine
H121N mutant, pH 7.6, competitive with deoxycytidine as substrate
Homo sapiens
2.7.1.21
0.004
deoxycytidine
H121N mutant, pH 7.6, non-competitive with thymidine as substrate
Homo sapiens
2.7.1.21
0.0049
thymidine
wild-type enzyme, pH 7.6, competitive with deoxycytidine as substrate
Homo sapiens
2.7.1.21
0.04
deoxycytidine
wild-type enzyme, pH 7.6, non-competitive with thymidine as substrate
Homo sapiens
Cloned(Commentary) (protein specific)
2.7.1.21
TK2
Homo sapiens
Engineering (protein specific)
2.7.1.21
H121N
similar subunit structure to wild-type enzyme, decreased enzyme activity
Homo sapiens
2.7.1.21
I212N
similar subunit structure to wild-type enzyme, less than 1% activity compared to wild-type
Homo sapiens
Inhibitors (protein specific)
2.7.1.21
dCTP
Homo sapiens
2.7.1.21
deoxcytidine
Homo sapiens
2.7.1.21
dTTP
Homo sapiens
2.7.1.21
thymidine
Homo sapiens
Ki Value [mM] (protein specific)
2.7.1.21
0.00036
dCTP
H121N mutant, pH 7.6, competitive with thymidine as substrate
Homo sapiens
2.7.1.21
0.00079
dCTP
wild-type enzyme, pH 7.6, competitive with thymidine as substrate
Homo sapiens
2.7.1.21
0.00087
dCTP
wild-type enzyme, pH 7.6, competitive with deoxycytidine as substrate
Homo sapiens
2.7.1.21
0.00089
dCTP
H121N mutant, pH 7.6, competitive with deoxycytidine as substrate
Homo sapiens
2.7.1.21
0.00089
dTTP
H121N mutant, pH 7.6, competitive with thymidine as substrate
Homo sapiens
2.7.1.21
0.002
dTTP
wild-type enzyme, pH 7.6, competitive with thymidine as substrate
Homo sapiens
2.7.1.21
0.0025
dTTP
wild-type and H121N mutant, pH 7.6, non-competitive with deoxycytidine as substrate
Homo sapiens
2.7.1.21
0.0036
thymidine
H121N mutant, pH 7.6, competitive with deoxycytidine as substrate
Homo sapiens
2.7.1.21
0.004
deoxycytidine
H121N mutant, pH 7.6, non-competitive with thymidine as substrate
Homo sapiens
2.7.1.21
0.0049
thymidine
wild-type enzyme, pH 7.6, competitive with deoxycytidine as substrate
Homo sapiens
2.7.1.21
0.04
deoxycytidine
wild-type enzyme, pH 7.6, non-competitive with thymidine as substrate
Homo sapiens
KM Value [mM] (protein specific)
2.7.1.21
0.0057
thymidine
H121N mutant, pH 7.6
Homo sapiens
2.7.1.21
0.011
deoxycytidine
wild-type and H121N mutant, pH 7.6
Homo sapiens
2.7.1.21
0.013
thymidine
wild-type, pH 7.6
Homo sapiens
2.7.1.21
0.018
thymidine
I212 mutant, pH 7.6
Homo sapiens
2.7.1.21
0.025
ATP
wild-type, thymidine as substrate, pH 7.6
Homo sapiens
2.7.1.21
0.037
ATP
wild-type, deoxycytidine as substrate, pH 7.6
Homo sapiens
2.7.1.21
0.059
ATP
I212 mutant, deoxycytidine as substrate, pH 7.6
Homo sapiens
2.7.1.21
0.08
ATP
H121N mutant, thymidine as substrate, pH 7.6
Homo sapiens
2.7.1.21
0.095
ATP
I212 mutant, thymidine as substrate, pH 7.6
Homo sapiens
2.7.1.21
0.162
ATP
H121N mutant, deoxycytidine as substrate, pH 7.6
Homo sapiens
2.7.1.21
0.568
deoxycytidine
I212 mutant, pH 7.6
Homo sapiens
Localization (protein specific)
2.7.1.21
mitochondrion
Homo sapiens
5739
Substrates and Products (Substrate) (protein specific)
2.7.1.21
ATP + 2'-deoxycytidine
641150
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate