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Literature summary extracted from

  • Taylor, A.T.; Stafford, M.A.; Jones, O.W.
    Properties of thymidine kinase partially purified from human fetal and adult tissue (1972), J. Biol. Chem., 247, 1930-1935.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.21 dCTP 80% inhibition of adult enzyme at 1 mM, almost no inhibition of fetal enzyme Homo sapiens
2.7.1.21 dTMP
-
Homo sapiens
2.7.1.21 dTTP
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.21 cytosol
-
Homo sapiens 5829
-
2.7.1.21 mitochondrion
-
Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.21 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.21 partial Homo sapiens
2.7.1.21 rLyTK1Val-106 and rLyTK1Met-106 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.21 fetus
-
Homo sapiens
-
2.7.1.21 liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.21 additional information
-
-
Homo sapiens

Storage Stability

EC Number Storage Stability Organism
2.7.1.21 -20°C, 50% glycerol, relatively stable Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.21 ATP + thymidine ATP can be substituted by dATP Homo sapiens ADP + dTMP
-
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Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.1.21 45
-
5 min, fetal liver: 50% loss of activity, adult liver: 10% loss of activity Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.21 7 8.5 adult liver Homo sapiens
2.7.1.21 7 7.2 fetal liver Homo sapiens