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Literature summary extracted from

  • Ellims, P.H.; van der Weyden, M.B.
    Kinetic mechanism and inhibition of human liver thymidine kinase (1981), Biochim. Biophys. Acta, 660, 238-242.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.21 ADP
-
 Homo sapiens
2.7.1.21 additional information overview: purine nucleotides, pyrimidine nucleotides Homo sapiens
2.7.1.21 TMP
-
 Homo sapiens
2.7.1.21 TTP
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.21 0.005
-
 thymidine pH 7.4, 37°C Homo sapiens
2.7.1.21 0.006
-
 deoxycytidine pH 7.4, 37°C Homo sapiens
2.7.1.21 0.09
-
 ATP pH 7.4, 37°C Homo sapiens
2.7.1.21 0.15
-
 CTP pH 7.4, 37°C Homo sapiens
2.7.1.21 0.26
-
 UTP pH 7.4, 37°C Homo sapiens
2.7.1.21 0.3
-
 GTP pH 7.4, 37°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.21 Mg2+
-
 Homo sapiens
2.7.1.21 Mn2+ can partially substitute for Mg2+ Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.21 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.21 ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.21 ATP + thymidine ATP can be substituted by UTP Homo sapiens ADP + dTMP
-
 ?
2.7.1.21 CTP + thymidine
-
 Homo sapiens CDP + thymidine 5'-phosphate
-
 ?
2.7.1.21 GTP + thymidine
-
 Homo sapiens GDP + thymidine 5'-phosphate
-
 ?
2.7.1.21 UTP + thymidine
-
 Homo sapiens UDP + dTMP
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.21 0.0085
-
 TTP competitive to ATP, pH 7.4, 37°C Homo sapiens
2.7.1.21 0.0135
-
 TTP competitive to thymidine, pH 7.4, 37°C Homo sapiens
2.7.1.21 0.63
-
 TMP pH 7.4, 37°C Homo sapiens
2.7.1.21 6.5
-
 ADP pH 7.4, 37°C Homo sapiens