EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.138 | transient expression in HEK293 cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.138 | F-12509A | 0.1 mM, 40-50% inhibition, sphingosine kinase inhibitor | Homo sapiens | |
2.7.1.138 | N,N-dimethylsphingosine | 0.1 mM, 65% inhibition | Homo sapiens | |
2.7.1.138 | sphingosine | 0.1 mM, 55% inhibition | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.138 | 0.032 | - |
ATP | pH 7.2, 30°C, recombinant ceramide kinase | Homo sapiens | |
2.7.1.138 | 0.19 | - |
ceramide | pH 7.2, 30°C, recombinant ceramide kinase | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.138 | Ca2+ | stimulation above 0.0001 mM, maximal activation at 0.5 mM | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.138 | Homo sapiens | Q8TCT0 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.138 | brain | mRNA level | Homo sapiens | - |
2.7.1.138 | heart | highest mRNA expression level | Homo sapiens | - |
2.7.1.138 | kidney | mRNA level | Homo sapiens | - |
2.7.1.138 | liver | mRNA level | Homo sapiens | - |
2.7.1.138 | skeletal muscle | mRNA level | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.138 | ATP + ceramide | no activity sphingosine, D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine and phyto-sphingosine | Homo sapiens | ADP + ceramide 1-phosphate | - |
? | |
2.7.1.138 | ATP + hexadecanoylceramide | C8 acyl chain, slightly higher activity than with natural ceramide | Homo sapiens | ADP + hexadecanoylceramide 1-phosphate | - |
? | |
2.7.1.138 | ATP + hexanoylceramide | C6 acyl chain, similar activity than with natural ceramide, very low activity with C2-ceramide and C6-dihydroceramide, no activity with C2-dihydroceramide | Homo sapiens | ADP + hexanoylceramide 1-phosphate | - |
? | |
2.7.1.138 | ATP + octanoylceramide | C8 acyl chain, higher activity than with natural ceramide | Homo sapiens | ADP + octanoylceramide 1-phosphate | - |
? | |
2.7.1.138 | ATP + octanoyldihydroceramide | C8 acyl chain, slightly higher activity than with natural ceramide | Homo sapiens | ADP + octanoyldihydroceramide 1-phosphate | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.138 | 6.5 | - |
- |
Homo sapiens |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.138 | 6 | 8 | approx. 25% of maximal activity at pH 6.0 and pH 8.0 | Homo sapiens |