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Literature summary extracted from

  • Karnitz, L.M.; Sutor, S.L.; Abraham, R.T.
    The Src-Family Kinase, Fyn, Regulates the Activation of Phosphatidylinositol 3-Kinase in an Interleukin 2-responsive T cell Line (1994), J. Exp. Med., 179, 1799-1808.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.137 additional information Fyn may be directly involved in the activation of the downstream signaling enzyme, PI3-kinase, in IL-2-stimulated T cells Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.137 additional information Mus musculus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Mus musculus
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-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.137 phosphoprotein IL-2 stimulation triggers tyrosine phosphorylation of the p85 subunit of PI3-kinase in murine T cell line CTLL-2 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.137 cell culture T cell line CTLL-2 Mus musculus
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2.7.1.137 T-lymphocyte T cell line CTLL-2 Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidylinositol
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 Mus musculus ADP + phosphatidylinositol 3-phosphate
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 ?
2.7.1.137 additional information
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 Mus musculus ?
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 ?