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Literature summary extracted from

  • Baynes, K.C.R.; Beeton, C.A.; Panayotou, G.; Stein, R.; Soos, M.; Hansen, T.; Simpson, H.; O'Rahilly, S.; Shepherd, P.R.; Whitehead, J.P.
    Natural variants of human p85a phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity (2000), Diabetologia, 43, 321-331.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.137 additional information the Arg409Gln p85a subunit of a natural variant is associated with lower insulin-stimulated phosphoinositide 3-kinase activity compared with wild-type, 15% reduction. The recruitment of Arg409Gln p85a into phosphotyrosine complexes is not significantly impaired. The impaired phosphoinositide 3-kinase activity of the Arg409Gln mutant suggests that it could contribute to the insulin resistance seen in this family. The Met326Ile p85a variant appears to have no functional effect on the insulin-stimulated phosphoinositide 3-kinase activity Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.137 additional information Homo sapiens plays a central part in the mediation of insulin-stimulated glucose disposal ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidylinositol
-
 Homo sapiens ADP + phosphatidylinositol 3-phosphate
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 ?
2.7.1.137 additional information plays a central part in the mediation of insulin-stimulated glucose disposal Homo sapiens ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.137 p85a phosphoinositide 3-kinase
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 Homo sapiens