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Literature summary extracted from

  • Ruiz-Larrea, F.; Vicendo, P.; Yaish, P.; End, P.; Panayotou, G.; Fry, M.J.; Morgan, S.J.; Thompson, A.; Parker, P.J.; Waterfield, M.D.
    Characterization of the bovine brain cytosolic phosphatidylinositol 3-kinase complex (1993), Biochem. J., 290, 609-616.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.137 5'-p-fluorosulfonylbenzoyladenosine
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.137 cytosol
-
 Bos taurus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.137 85000
-
 1 * 110000 + 1 * 85000, enzyme form PI3KII, SDS-PAGE Bos taurus
2.7.1.137 85000
-
 1 * 85000 + 1 * 110000 Bos taurus
2.7.1.137 110000
-
 1 * 110000 + 1 * 85000, enzyme form PI3KII, SDS-PAGE Bos taurus
2.7.1.137 110000
-
 1 * 85000 + 1 * 110000 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.137 additional information Bos taurus receptor linked enzyme may generate a second-messenger signal ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Bos taurus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.137 phosphoprotein purified enzyme complex is highly phosphorylated on both subunits, dephosphorylation generates a deactivated complex Bos taurus
2.7.1.137 phosphoprotein highly phosphorylated on both p85a and p110 subunits, and dephosphorylation generates a deactivated complex, indicating that phosphorylation is an important covalent modification of the complex and may modulate PtdIns 3-kinase activity Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.137 large scale Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.137 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidylinositol
-
 Bos taurus ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.137 additional information receptor linked enzyme may generate a second-messenger signal Bos taurus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.137 dimer 1 * 110000 + 1 * 85000, enzyme form PI3KII, SDS-PAGE Bos taurus
2.7.1.137 dimer 1 * 85000 + 1 * 110000 Bos taurus
2.7.1.137 More the 110000 Da subunit contains an ATP-binding site Bos taurus

Synonyms

EC Number Synonyms Comment Organism
2.7.1.137 receptor-linked phosphatidylinositol 3-kinase
-
 Bos taurus