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Literature summary extracted from

  • Morgan, S.J.; Smith, A.D.; Parker, P.J.
    Purification and characterization of bovine brain type I phosphatidylinositol kinase (1990), Eur. J. Biochem., 191, 761-767.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.137 Mg2+ inhibition above 2.5 mM, activation below Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.137 0.034
-
 phosphatidylinositol sonicated Bos taurus
2.7.1.137 0.067
-
 ATP
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.137 Mg2+ activation Bos taurus
2.7.1.137 Mg2+ Km: 6.9 mM Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.137 85000
-
 x * 85000, SDS-PAGE Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.137 type I phosphatidylinositol kinase Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.137 brain
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.137 0.0017
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidylinositol
-
 Bos taurus ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.137 ATP + phosphatidylinositol 4,5-bisphosphate weak activity Bos taurus ADP + phosphatidylinositol 3,4,5-trisphosphate
-
 ?
2.7.1.137 ATP + phosphatidylinositol 4-phosphate weak activity Bos taurus ADP + phosphatidylinositol 3,4-bisphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.137 ? x * 85000, SDS-PAGE Bos taurus