Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Yang, X.; Shears, B.S.
    Multitasking in signal transduction by a promiscuous human ins(3,4,5,6)P4 1-kinase/ins(1,3,4)P3 5/6-kinase (2000), Biochem. J., 351, 551-555.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.134 expression in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.134 S356N same catalytic activity as wild-type Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.134 0.0001
-
 myo-inositol-3,4,5,6-tetrakisphosphate pH 7.2, 37°C, recombinant enzyme Homo sapiens
2.7.1.134 0.0002
-
 myo-inositol-3,4,6-trisphosphate pH 7.2, 37°C, recombinant enzyme Homo sapiens
2.7.1.134 0.0003
-
 myo-inositol-1,3,4-trisphosphate pH 7.2, 37°C, recombinant enzyme Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.134 47000
-
 x * 47000, deduced from nucleotide sequence Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.134 Homo sapiens Q13572
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate enzyme has both inositol-3,4,5,6-tetrakisphosphate 1-kinase and inositol-1,3,4-trisphosphate 5/6 kinase activity, 2 times higher activity than with inositol-1,3,4-trisphosphate, no activity with inositol-1,4-bisphosphate, inositol-1,4,5-trisphosphate, inositol-1,3,4,5-tetrakisphosphate, inositol-1,3,4,6-tetrakisphosphate or inositol-1,3,4,5,6-pentakisphosphate Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.134 ATP + myo-inositol-3,4,6-trisphosphate
-
 Homo sapiens ADP + myo-inositol-1,3,4,6-tetrakisphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.134 ? x * 47000, deduced from nucleotide sequence Homo sapiens