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Literature summary extracted from

  • Kishimoto, A.; Brown, M.S.; Slaughter, C.A.; Goldstein, J.L.
    Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II (1987), J. Biol. Chem., 262, 1344-1351.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.29 additional information no activation by polylysine Bos taurus

General Stability

EC Number General Stability Organism
2.7.11.29 high salt concentrations, e.g. 1 mM NaCl, inactivate Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.29 heparin strong Bos taurus
2.7.11.29 Low-density lipoprotein receptor above 10 nM, spermine protects Bos taurus
2.7.11.29 additional information no inhibition by cAMP, cGMP, Ca2+/calmodulin, Ca2+/phosphatidylserine or N-ethylmaleimide Bos taurus
2.7.11.29 polylysine strong Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.29 0.000005
-
 Low-density lipoprotein receptor 30°C, pH 7.5 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.29 cytosol
-
 Bos taurus 5829
-
2.7.11.29 soluble
-
 Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.29 ATP + low-density lipoprotein receptor Bos taurus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.29 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.29 partial Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.29 adrenal gland cortex Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.29 0.0033
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.29 ATP + casein
-
 Bos taurus ?
-
 ?
2.7.11.29 ATP + low-density lipoprotein receptor
-
 Bos taurus ?
-
 ?
2.7.11.29 ATP + low-density lipoprotein-L-serine phosphorylates the Ser-833 in the cytoplasmic domain of the low-density lipoprotein receptor Bos taurus ADP + low-density lipoprotein O-phospho-L-serine
-
 ?
2.7.11.29 ATP + low-density lipoprotein-L-serine GTP can replace ATP to some extent Bos taurus ADP + low-density lipoprotein O-phospho-L-serine
-
 ?
2.7.11.29 ATP + low-density lipoprotein-L-serine no substrates are protamine or histamine Bos taurus ADP + low-density lipoprotein O-phospho-L-serine
-
 ?
2.7.11.29 ATP + phosvitin
-
 Bos taurus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.29 dimer
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.29 30
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.29 7.5
-
 assay at Bos taurus