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Literature summary extracted from

  • Schell, M.J.; Erneux, C.; Irvine, R.F.
    Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus (2001), J. Biol. Chem., 276, 37537-37546.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.127 CaM kinase II endogenous activator of isoform A Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.127 full-length and truncated isoenzyme A is cloned and expressed in HeLa cells, COS-7 cells and primary neuronal cultures Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.127 actin filament recombinant isoenzyme A has an N-terminal 66-amino acid F-actin-binding region, isoform A co-localizes with F-actin Rattus norvegicus 5884
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2.7.1.127 cytoskeleton recombinant isoenzyme A associates with the cytoskeleton, targeting of IP3kin A to the actin cytoskeleton in transfected HeLa and COS-7 cells Rattus norvegicus 5856
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2.7.1.127 dendrite recombinant isoenzyme A has an N-terminal 66-amino acid F-actin-binding region that localizes the kinase to dentritic spines, endogenous isoenzyme A is localized to the dentritic spines of pyramidal neurons in primary hippocampal cultures Rattus norvegicus 30425
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2.7.1.127 plasma membrane recombinant isoenzyme A associates with Rattus norvegicus 5886
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus phosphorylation of IP3 in dentritic spines to produce IP4 is important for modulating the compartmentalization of calcium at synapses, control of calcium signals, the rapid, localized synthesis of IP4 may have complex effects on cytosolic calcium and on the molecular mechanisms that control learning and memory ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Rattus norvegicus
-
 isoenzyme A
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 astrocyte highest expression of recombinant isoenzyme A in astrocytes of hippocampal cultures transfected with isoenzyme A Rattus norvegicus
-
2.7.1.127 brain isoform A Rattus norvegicus
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2.7.1.127 hippocampus endogenous isoenzyme A is localized to the dentritic spines of pyramidal neurons in primary hippocampal cultures from neonatal rats, highest expression of recombinant isoenzyme A in astrocytes Rattus norvegicus
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2.7.1.127 neuron endogenous isoenzyme A is localized to the dentritic spines of pyramidal neurons in primary hippocampal cultures Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate isoform A: N-terminal 66-amino acid F-actin-binding region Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate phosphorylation of IP3 in dentritic spines to produce IP4 is important for modulating the compartmentalization of calcium at synapses, control of calcium signals, the rapid, localized synthesis of IP4 may have complex effects on cytosolic calcium and on the molecular mechanisms that control learning and memory Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
 Rattus norvegicus