EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | Ca2+ | isoenzyme C is regulated by Ca2+ to a lesser extend than isoenzymes A and B | Homo sapiens | |
2.7.1.127 | Ca2+ | activation by Ca2+/calmodulin | Mammalia | |
2.7.1.127 | Ca2+ | activation by Ca2+/calmodulin | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | - |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | Mammalia | role in rapidly metabolizing the pool of Ins(1,4,5)P3 that is generated when phospholipase C-coupled receptors are activated, the product Ins(1,3,4,5)P4 can protect Ins(1,4,5)P3 against hydrolysis and therefore increase its effectiveness, detailed consequences of Ins(1,3,4,5)P4 generation in the cell, all 3 isoenzymes are regulated by calmodulin, 2 isoenzymes are regulated by a Ca2+/calmodulin-dependent protein kinase II | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.127 | Homo sapiens | - |
3 isoenzymes: A, B and C | - |
2.7.1.127 | Mammalia | - |
at least 3 isoforms: A, B and C | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.127 | additional information | isoenzyme C is not found in brain | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Mammalia | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | role in rapidly metabolizing the pool of Ins(1,4,5)P3 that is generated when phospholipase C-coupled receptors are activated, the product Ins(1,3,4,5)P4 can protect Ins(1,4,5)P3 against hydrolysis and therefore increase its effectiveness, detailed consequences of Ins(1,3,4,5)P4 generation in the cell, all 3 isoenzymes are regulated by calmodulin, 2 isoenzymes are regulated by a Ca2+/calmodulin-dependent protein kinase II | Mammalia | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | ATP | - |
Mammalia | |
2.7.1.127 | ATP | - |
Homo sapiens | |
2.7.1.127 | Calmodulin | activation by Ca2+/calmodulin | Mammalia | |
2.7.1.127 | Calmodulin | activation by Ca2+/calmodulin | Homo sapiens |