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Literature summary extracted from

  • Choi, G.; Chang, Y.T.; Chung, S.K.; Choi, K.Y.
    Molecular interactions of all possible regioisomers of synthetic myo-inositol phosphates with inositol 1,4,5-trisphosphate 3-kinase (1997), Bioorg. Med. Chem. Lett., 7, 2709-2714.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.127 IP3K is overexpressed in Escherichia coli Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.127 inositol phosphate inhibitory effects of all possible 38 regioisomers of synthetic inositol phosphates, only inositol trisphosphates and tetrakisphosphates inhibit, not or very weak: inositol monophosphates, bisphosphates and pentakisphosphates, the recognition of myo-inositol phosphate regioisomers is highly structure-selective Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus inositol phosphate metabolism ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Rattus norvegicus
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recombinant IP3K overexpressed in Escherichia coli
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Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.127 recombinant IP3K overexpressed in Escherichia coli Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 brain
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Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate environment of the active site, proposed binding site model for Ins(1,4,5)P3 Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate inositol phosphate metabolism Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP ATP-dependent Rattus norvegicus