Literature summary extracted from
Choi, G.; Chang, Y.T.; Chung, S.K.; Choi, K.Y.
Molecular interactions of all possible regioisomers of synthetic myo-inositol phosphates with inositol 1,4,5-trisphosphate 3-kinase (1997), Bioorg. Med. Chem. Lett., 7, 2709-2714.
No PubMed abstract available
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
2.7.1.127 |
IP3K is overexpressed in Escherichia coli |
Rattus norvegicus |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
2.7.1.127 |
inositol phosphate |
inhibitory effects of all possible 38 regioisomers of synthetic inositol phosphates, only inositol trisphosphates and tetrakisphosphates inhibit, not or very weak: inositol monophosphates, bisphosphates and pentakisphosphates, the recognition of myo-inositol phosphate regioisomers is highly structure-selective |
Rattus norvegicus |
|
Natural Substrates/ Products (Substrates)
EC Number |
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
---|
2.7.1.127 |
ATP + 1D-myo-inositol 1,4,5-trisphosphate |
Rattus norvegicus |
inositol phosphate metabolism |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate |
- |
? |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.7.1.127 |
Rattus norvegicus |
- |
recombinant IP3K overexpressed in Escherichia coli |
- |
Purification (Commentary)
EC Number |
Purification (Comment) |
Organism |
---|
2.7.1.127 |
recombinant IP3K overexpressed in Escherichia coli |
Rattus norvegicus |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
2.7.1.127 |
brain |
- |
Rattus norvegicus |
- |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
2.7.1.127 |
ATP + 1D-myo-inositol 1,4,5-trisphosphate |
environment of the active site, proposed binding site model for Ins(1,4,5)P3 |
Rattus norvegicus |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate |
- |
? |
|
2.7.1.127 |
ATP + 1D-myo-inositol 1,4,5-trisphosphate |
inositol phosphate metabolism |
Rattus norvegicus |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate |
- |
? |
|
Cofactor
EC Number |
Cofactor |
Comment |
Organism |
Structure |
---|
2.7.1.127 |
ATP |
ATP-dependent |
Rattus norvegicus |
|